Protein Summary
Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016]
- ENST00000225371
- ENSP00000225371
- ENSG00000121053
- EPER
- EPO
- EPP
- EPO
- EPP
- EPXD
- EPX-PEN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
pathway | 0.59 | ||
chemical | 0.52 | ||
gene perturbation | 0.49 | ||
molecular function | 0.49 | ||
cell type or tissue | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 303.97 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 355 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 303.97 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 355 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 6
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0