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Tbio
EPS8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

Protein Summary
Description
Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. At least two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000201647
  • ENSP00000201647
  • ENSG00000131037
  • ENST00000245618
  • ENSP00000245618

Symbol
  • DRC3
  • EPS8R1
  • DRC3
  • EPS8R1
  • PP10566
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
gene perturbation
0.66
cell line
0.57
tissue sample
0.56
cellular component
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.21   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
BAIAP2
Tbio
Novelty:  0.00949996
p_int:  0.999978408
p_ni:  0.000021592
Score:  0.19
Data Source:  BioPlex,STRINGDB
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.99980351
p_ni:  0.000194211
p_wrong:  0.000002279
Data Source:  BioPlex
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999619402
p_ni:  0.000380598
Data Source:  BioPlex
ARHGAP27
Tdark
Family:  Enzyme
Novelty:  0.3068719
p_int:  0.999451691
p_ni:  2.4e-8
p_wrong:  0.000548284
Data Source:  BioPlex
CYFIP2
Tbio
Novelty:  0.01910939
p_int:  0.999351018
p_ni:  0.000648982
Data Source:  BioPlex
WASF2
Tbio
Novelty:  0.00968798
p_int:  0.998778755
p_ni:  0.001221245
Data Source:  BioPlex
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.997794873
p_ni:  0.002205127
Score:  0.493
Data Source:  BioPlex,STRINGDB
C1QBP
Tbio
Novelty:  0.00532825
p_int:  0.996250627
p_ni:  0.003749373
Data Source:  BioPlex
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.995836775
p_ni:  0.004163225
Score:  0.672
Data Source:  BioPlex,STRINGDB
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.995158975
p_ni:  0.004811111
p_wrong:  0.000029913
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
97.4
reticulocyte count
4
3
5
94.1
reticulocyte measurement
2
2
3
90.9
platelet crit
2
3
4
89.1
mean corpuscular volume
1
4
4
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
97.4
reticulocyte count
5
94.1
reticulocyte measurement
3
90.9
platelet crit
4
89.1
mean corpuscular volume
4
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
EPS8 like 1
698281
Mouse
MGI:1914675
67425
Rat
RGD:1311146
361503
Dog
EPS8 like 1
VGNC:40428
484302
Horse
EPS8 like 1
VGNC:17638
100147201
Species
Name
OMA
EggNOG
Inparanoid
Macaque
EPS8 like 1
Mouse
Rat
Dog
EPS8 like 1
Horse
EPS8 like 1
Publication Statistics
PubMed Score 5.21
PubMed score by year
PubTator Score 3.70
PubTator score by year
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Related Publications
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PMID
Year
Title