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Tbio
EPS8
Epidermal growth factor receptor kinase substrate 8

Protein Summary
Description
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filop ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281172
  • ENSP00000281172
  • ENSG00000151491
  • ENST00000540613
  • ENSP00000441888
  • ENST00000542903
  • ENSP00000437806
  • ENST00000543523
  • ENSP00000441867
  • ENST00000543612
  • ENSP00000442388
  • ENST00000642278
  • ENSP00000494689
  • ENST00000644374
  • ENSP00000495956
  • ENST00000645775
  • ENSP00000495824
  • ENST00000646828
  • ENSP00000494842
  • ENST00000646918
  • ENSP00000495722
  • ENST00000647087
  • ENSP00000496406
  • ENST00000647224
  • ENSP00000496516

Symbol
  • DFNB102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
gene perturbation
0.83
interacting protein
0.81
PubMedID
0.81
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.79   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 127.79   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (98)
BAIAP2
Tbio
Novelty:  0.00949996
p_int:  0.999999996
p_ni:  4e-9
Score:  0.986
Data Source:  BioPlex,STRINGDB
AMPD2
Tchem
Family:  Enzyme
Novelty:  0.01510718
p_int:  0.999994244
p_ni:  0.00000571
p_wrong:  4.6e-8
Score:  0.193
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.995589778
p_ni:  0.000030034
p_wrong:  0.004380187
Score:  0.183
Data Source:  BioPlex,STRINGDB
USP6NL
Tbio
Novelty:  0.09667588
Score:  0.996
Data Source:  STRINGDB
ABI1
Tbio
Novelty:  0.00796638
Score:  0.994
Data Source:  STRINGDB
SOS1
Tchem
Novelty:  0.00285343
Score:  0.993
Data Source:  STRINGDB
EGFR
Tclin
Family:  Kinase
Novelty:  0.00007274
Score:  0.982
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.958
Data Source:  STRINGDB
CDC42
Tchem
Family:  Enzyme
Novelty:  0.00032619
Score:  0.956
Data Source:  STRINGDB
ABL1
Tclin
Family:  Kinase
Novelty:  0.00023803
Score:  0.946
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (62)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Regulation of RAC1 activity
PathwayCommons: pid
ErbB1 downstream signaling
PathwayCommons: pid
PDGFR-beta signaling pathway
PathwayCommons: netpath
EGFR1
PathwayCommons: pid
CDC42 signaling events
Name
Explore in Pharos
Explore in Source
Regulation of RAC1 activity
ErbB1 downstream signaling
PDGFR-beta signaling pathway
EGFR1
CDC42 signaling events
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
1
1
31.4
self reported educational attainment
1
1
1
24.5
mental process
1
1
0
1.1
24.5
mathematical ability
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
1
31.4
self reported educational attainment
1
24.5
mental process
0
1.1
24.5
mathematical ability
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor pathway substrate 8
VGNC:5366
473379
Macaque
epidermal growth factor receptor pathway substrate 8
702777
Mouse
MGI:104684
13860
Rat
RGD:1310590
312812
Dog
epidermal growth factor receptor pathway substrate 8
VGNC:40427
477686
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor pathway substrate 8
Macaque
epidermal growth factor receptor pathway substrate 8
Mouse
Rat
Dog
epidermal growth factor receptor pathway substrate 8
Publication Statistics
PubMed Score 127.79
PubMed score by year
PubTator Score 67.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title