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Tbio
EPS8
Epidermal growth factor receptor kinase substrate 8

Protein Summary
Description
Signaling adapter that controls various cellular protrusions by regulating actin cytoskeleton dynamics and architecture. Depending on its association with other signal transducers, can regulate different processes. Together with SOS1 and ABI1, forms a trimeric complex that participates in transduction of signals from Ras to Rac by activating the Rac-specific guanine nucleotide exchange factor (GEF) activity. Acts as a direct regulator of actin dynamics by binding actin filaments and has both barbed-end actin filament capping and actin bundling activities depending on the context. Displays barbed-end actin capping activity when associated with ABI1, thereby regulating actin-based motility process: capping activity is auto-inhibited and inhibition is relieved upon ABI1 interaction. Also shows actin bundling activity when associated with BAIAP2, enhancing BAIAP2-dependent membrane extensions and promoting filopodial protrusions. Involved in the regulation of processes such as axonal filop ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281172
  • ENSP00000281172
  • ENSG00000151491
  • ENST00000540613
  • ENSP00000441888
  • ENST00000542903
  • ENSP00000437806
  • ENST00000543523
  • ENSP00000441867
  • ENST00000543612
  • ENSP00000442388
  • ENST00000642278
  • ENSP00000494689
  • ENST00000644374
  • ENSP00000495956
  • ENST00000645775
  • ENSP00000495824
  • ENST00000646828
  • ENSP00000494842
  • ENST00000646918
  • ENSP00000495722
  • ENST00000647087
  • ENSP00000496406
  • ENST00000647224
  • ENSP00000496516

Symbol
  • DFNB102
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.84
gene perturbation
0.83
interacting protein
0.81
PubMedID
0.81
cellular component
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.76   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 347   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.76   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 347   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0