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Tchem
EPS15
Epidermal growth factor receptor substrate 15

Protein Summary
Description
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by Ref ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371733
  • ENSP00000360798
  • ENSG00000085832

Symbol
  • AF1P
  • AF1P
  • AF-1P
  • MLLT5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
drug perturbation
0.96
interacting protein
0.93
hub protein
0.9
cellular component
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.09   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.09   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (316)
AP2M1
Tbio
Novelty:  0.00769368
p_int:  0.999999886
p_ni:  1.14e-7
Score:  0.97
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.999999787
p_ni:  2.13e-7
Score:  0.931
Data Source:  BioPlex,STRINGDB
AP2S1
Tbio
Novelty:  0.01931502
p_int:  0.999999742
p_ni:  2.58e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
SPC25
Tbio
Novelty:  0.26354244
p_int:  0.999999225
p_ni:  7.75e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.99999907
p_ni:  9.3e-7
Score:  0.638
Data Source:  BioPlex,STRINGDB
LSR
Tbio
Novelty:  0.00528058
p_int:  0.999987547
p_ni:  0.000012453
Data Source:  BioPlex
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999888679
p_ni:  0.000111321
Data Source:  BioPlex
FCHO1
Tbio
Novelty:  0.10512826
p_int:  0.999855042
p_ni:  0.000144902
p_wrong:  5.6e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
MACC1
Tbio
Novelty:  0.00737376
p_int:  0.999575643
p_ni:  0.000424357
Score:  0.527
Data Source:  BioPlex,STRINGDB
AURKA
Tchem
Family:  Kinase
Novelty:  0.0010868
p_int:  0.998471055
p_ni:  0.001528945
Score:  0.211
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Disease
Reactome
EGFR downregulation
Reactome
Infectious disease
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Disease
EGFR downregulation
Infectious disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
61.8
BMI-adjusted hip circumference
1
2
2
51.4
electrocardiography
1
1
6
44.2
lymphocyte percentage of leukocytes
1
1
1
28.1
blood urea nitrogen measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
61.8
BMI-adjusted hip circumference
2
51.4
electrocardiography
6
44.2
lymphocyte percentage of leukocytes
1
28.1
blood urea nitrogen measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor pathway substrate 15
VGNC:536
456850
Macaque
epidermal growth factor receptor pathway substrate 15
714767
Mouse
MGI:104583
13858
Rat
RGD:1305550
313474
Dog
epidermal growth factor receptor pathway substrate 15
VGNC:54202
475356
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor pathway substrate 15
Macaque
epidermal growth factor receptor pathway substrate 15
Mouse
Rat
Dog
epidermal growth factor receptor pathway substrate 15
Publication Statistics
PubMed Score 187.09
PubMed score by year
PubTator Score 146.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title