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Tdark
EPPK1
Epiplakin

Protein Summary
Description
Cytoskeletal linker protein that connects to intermediate filaments and controls their reorganization in response to stress (PubMed:15671067, PubMed:27206504, PubMed:23398049). In response to mechanical stress like wound healing, is associated with the machinery for cellular motility by slowing down keratinocyte migration and proliferation and accelerating keratin bundling in proliferating keratinocytes thus contributing to tissue architecture (PubMed:27206504, PubMed:23398049). However in wound healing in corneal epithelium also positively regulates cell differentiation and proliferation and negatively regulates migration thereby controlling corneal epithelium morphogenesis and integrity. In response to cellular stress, plays a role in keratin filament reorganization, probably by protecting keratin filaments against disruption. During liver and pancreas injuries, plays a protective role by chaperoning disease-induced intermediate filament reorganization (By similarity). The protein en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000615648
  • ENSP00000484472
  • ENSG00000261150

Symbol
  • EPIPL
  • EPIPL
  • EPIPL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
transcription factor perturbation
0.84
ligand (protein) perturbation
0.83
gene perturbation
0.69
virus perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.96   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.96   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.999725232
p_ni:  0.000274768
Data Source:  BioPlex
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999641815
p_ni:  0.000358185
Data Source:  BioPlex
MUM1
Tbio
Family:  Epigenetic
Novelty:  0.11597088
p_int:  0.99658998
p_ni:  0.00341002
Data Source:  BioPlex
CDK15
Tchem
Family:  Kinase
Novelty:  0.3870338
p_int:  0.988088544
p_ni:  0.011911456
Score:  0.158
Data Source:  BioPlex,STRINGDB
DDX19B
Tbio
Family:  Enzyme
Novelty:  0.0504568
p_int:  0.970734011
p_ni:  0.029265989
Data Source:  BioPlex
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.961248366
p_ni:  0.038751634
Data Source:  BioPlex
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.954826324
p_ni:  0.045173676
Data Source:  BioPlex
ZSCAN12
Tdark
Family:  TF
Novelty:  0.33578207
p_int:  0.952640628
p_ni:  0.047359372
Data Source:  BioPlex
RBM24
Tbio
Novelty:  0.04562076
p_int:  0.922686
p_ni:  0.077314
Score:  0.195
Data Source:  BioPlex,STRINGDB
VIM
Tbio
Novelty:  0.00030317
p_int:  0.84471048
p_ni:  0.15528952
Score:  0.28
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
7
9
97.4
platelet count
5
3
4
2.3
96.9
total cholesterol measurement
4
4
4
87.6
mean platelet volume
2
1
2
75.7
platelet crit
1
1
1
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
9
97.4
platelet count
4
2.3
96.9
total cholesterol measurement
4
87.6
mean platelet volume
2
75.7
platelet crit
1
74.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Opossum
epiplakin 1
100017139
Anole lizard
epiplakin 1 [Source:HGNC Symbol;Acc:HGNC:15577]
Zebrafish
ZDB-GENE-030416-1
101885652
Species
Name
OMA
EggNOG
Inparanoid
Opossum
epiplakin 1
Anole lizard
epiplakin 1 [Source:HGNC Symbol;Acc:HGNC:15577]
Zebrafish
Publication Statistics
PubMed Score 39.96
PubMed score by year
PubTator Score 15.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title