Tclin EPOR Erythropoietin receptor

Protein Summary

Description

Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate the LYN tyrosine kinase. Isoform EPOR-T acts as a dominant-negative receptor of EPOR-mediated signaling. This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• P19235
• B2RCG4
• Q15443
• Q2M205
• EPO-R

Gene Name

• EPOR

Ensembl ID

• ENST00000222139
• ENSP00000222139
• ENSG00000187266
• ENST00000592375
• ENSP00000467809

Symbol

• EPO-R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.92
hub protein	0.9
kinase perturbation	0.84
virus perturbation	0.76
gene perturbation	0.74

Protein Classes

PANTHER Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Erythropoietin Receptor

DTO Classes

Protein / Receptor / Cytokine Receptor / Type I Cytokine Receptor / Erythropoietin Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.67   (req: < 5)

Gene RIFs: 161   (req: <= 3)

Antibodies: 822   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.67   (req: >= 5)

Gene RIFs: 161   (req: > 3)

Antibodies: 822   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7