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Tdark
EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

Protein Summary
Description
Scaffold protein that serves as a bridging partner between the PRC2/EED-EZH2 complex and the elongin BC complex: required to fine-tune the transcriptional status of Polycomb group (PcG) target genes in embryonic stem cells (ESCs). Plays a key role in genomic regions that display both active and repressive chromatin properties in pluripotent stem cells by sustaining low level expression at PcG target genes: acts by recruiting the elongin BC complex, thereby restricting excessive activity of the PRC2/EED-EZH2 complex. Interaction with USP7 promotes deubiquitination of H2B at promoter sites. Acts as a regulator of neuronal differentiation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621654
  • ENSP00000484710
  • ENSG00000273604

Symbol
  • C17orf96
  • PRR28
  • PRR28
  • C17orf96
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.25   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 18   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.25   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 18   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
p_int:  0.999999994
p_ni:  1e-9
p_wrong:  5e-9
Score:  0.766
Data Source:  BioPlex,STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
p_int:  0.999999811
p_ni:  1e-9
p_wrong:  1.88e-7
Score:  0.767
Data Source:  BioPlex,STRINGDB
AEBP2
Tbio
Novelty:  0.05974483
Score:  0.788
Data Source:  STRINGDB
EED
Tchem
Novelty:  0.00615758
Score:  0.762
Data Source:  STRINGDB
MTF2
Tbio
Family:  Epigenetic
Novelty:  0.01152147
Score:  0.754
Data Source:  STRINGDB
EZH1
Tchem
Family:  Epigenetic
Novelty:  0.02636757
Score:  0.742
Data Source:  STRINGDB
JARID2
Tbio
Family:  TF; Epigenetic
Novelty:  0.00921097
Score:  0.718
Data Source:  STRINGDB
PHF19
Tbio
Family:  Epigenetic
Novelty:  0.02289037
Score:  0.701
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.698
Data Source:  STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
Score:  0.656
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
1
1
78.4
body height
2
1
2
68
heel bone mineral density
2
1
2
52.4
forced expiratory volume
1
1
1
46.9
1
1
0
1.1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
1
78.4
body height
2
68
heel bone mineral density
2
52.4
forced expiratory volume
1
46.9
0
1.1
3.8
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 17.25
PubMed score by year
PubTator Score 1.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title