You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EPN2
Epsin-2

Protein Summary
Description
Plays a role in the formation of clathrin-coated invaginations and endocytosis. This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314728
  • ENSP00000320543
  • ENSG00000072134
  • ENST00000347697
  • ENSP00000261495
  • ENST00000395618
  • ENSP00000378980
  • ENST00000395620
  • ENSP00000378982

Symbol
  • KIAA1065
  • EHB21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
kinase perturbation
0.76
transcription factor perturbation
0.68
transcription factor
0.66
kinase
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.98   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 291   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.98   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 291   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0