Protein Summary
Plays a role in the formation of clathrin-coated invaginations and endocytosis. This gene encodes a protein which interacts with clathrin and adaptor-related protein complex 2, alpha 1 subunit. The protein is found in a brain-derived clathrin-coated vesicle fraction and localizes to the peri-Golgi region and the cell periphery. The protein is thought to be involved in clathrin-mediated endocytosis. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- ENST00000314728
- ENSP00000320543
- ENSG00000072134
- ENST00000347697
- ENSP00000261495
- ENST00000395618
- ENSP00000378980
- ENST00000395620
- ENSP00000378982
- KIAA1065
- EHB21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.79 | ||
kinase perturbation | 0.76 | ||
transcription factor perturbation | 0.68 | ||
transcription factor | 0.66 | ||
kinase | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.98 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 291 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 61.98 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 291 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0