Tbio EPN1 Epsin-1

Protein Summary

Description

Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9Y6I3
• Q86ST3
• Q9HA18

Gene Name

• EPN1

Ensembl ID

• ENST00000085079
• ENSP00000085079
• ENSG00000063245
• ENST00000270460
• ENSP00000270460
• ENST00000411543
• ENSP00000406209

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.89
disease perturbation	0.87
transcription factor	0.78
transcription factor binding site profile	0.78
kinase perturbation	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 200   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.67   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (195)

Explore Interacting Targets

1 – 10 of 195

• See Interactions on String-DB

EPN3

Tbio

Novelty:  0.12685855

p_int:  0.999999974

p_ni:  2.6e-8

Score:  0.876

Data Source:  BioPlex,STRINGDB

GAS2L1

Tbio

Novelty:  0.17484834

p_int:  0.999990323

p_ni:  0.000009677

Score:  0.232

Data Source:  BioPlex,STRINGDB

LDLRAD4

Tbio

Novelty:  0.04881486

p_int:  0.999987472

p_ni:  0.000012528

Data Source:  BioPlex

KIF20A

Tchem

Novelty:  0.01640924

p_int:  0.999956127

p_ni:  0.000043868

p_wrong:  5e-9

Data Source:  BioPlex

SLC2A14

Tbio

Family:  Transporter

Novelty:  0.00247741

p_int:  0.998045393

p_ni:  0.001954607

Score:  0.198

Data Source:  BioPlex,STRINGDB

TADA2B

Tbio

Family:  TF

Novelty:  0.06387677

p_int:  0.997125753

p_ni:  0.002874024

p_wrong:  2.22e-7

Score:  0.185

Data Source:  BioPlex,STRINGDB

RAB33B

Tbio

Family:  Enzyme

Novelty:  0.06381712

p_int:  0.991793495

p_ni:  0.008201103

p_wrong:  0.000005403

Data Source:  BioPlex

FLVCR2

Tbio

Novelty:  0.02871146

p_int:  0.98990895

p_ni:  0.01009064

p_wrong:  4.1e-7

Score:  0.382

Data Source:  BioPlex,STRINGDB

PLPPR2

Tdark

Family:  Enzyme

Novelty:  1.03318406

p_int:  0.989005207

p_ni:  0.010994729

p_wrong:  6.4e-8

Score:  0.198

Data Source:  BioPlex,STRINGDB

AP2M1

Tbio

Novelty:  0.00769368

p_int:  0.967025472

p_ni:  0.032193139

p_wrong:  0.000781389

Score:  0.964

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (13)

Reactome (8)

KEGG (1)

PathwayCommons (2)

WikiPathways (2)

Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Items per page:

5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Reactome	Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
Reactome	EGFR downregulation	31 targets	R-HSA-182971
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	Signal Transduction	2704 targets	R-HSA-162582

Name	Explore in Pharos	Explore in Source
Cargo recognition for clathrin-mediated endocytosis	105 targets	R-HSA-8856825
Clathrin-mediated endocytosis	143 targets	R-HSA-8856828
EGFR downregulation	31 targets	R-HSA-182971
Membrane Trafficking	612 targets	R-HSA-199991
Signal Transduction	2704 targets	R-HSA-162582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (13)

Functions (1)

Components (4)

Processes (8)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
lipid binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations (null)

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menopause	EFO_0004704	2	2	3		77.1
triglyceride measurement	EFO_0004530	3	2	3		72.7
insomnia measurement	EFO_0007876	1	2	0	1.1	56.3
parental genotype effect measurement	EFO_0005939	1	1	1		46.9
birth weight	EFO_0004344	1	1	1		46.9

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
age at menopause	EFO_0004704	3		77.1
triglyceride measurement	EFO_0004530	3		72.7
insomnia measurement	EFO_0007876	0	1.1	56.3
parental genotype effect measurement	EFO_0005939	1		46.9
birth weight	EFO_0004344	1		46.9

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Coated pit
Complete proteome
Cytoplasm
Endocytosis
Lipid-binding
Membrane
Methylation

GWAS Trait Find Similar Targets

No Header	No Header
age at menopause
birth weight
high density lipoprotein cholesterol measurement
insomnia measurement
parental genotype effect measurement
triglyceride measurement

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	epsin 1	VGNC:2389	737301
Macaque	epsin 1		702956
Mouse	epsin 1	MGI:1333763	13854
Rat	Epsin 1	RGD:619772	117277
Dog	epsin 1	VGNC:40419	608964

Species	Name	OMA	EggNOG	Inparanoid
Chimp	epsin 1
Macaque	epsin 1
Mouse	epsin 1
Rat	Epsin 1
Dog	epsin 1

Publication Statistics

PubMed Score 54.67

PubMed score by year

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PubTator Score 28.73

PubTator score by year

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Related Publications

Text Mined References (30)

GeneRif Annotations (10)

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10

0 of 0

PMID	Year	Title