Protein Summary
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis. This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain cancer types. [provided by RefSeq, Mar 2016]
- ENST00000085079
- ENSP00000085079
- ENSG00000063245
- ENST00000270460
- ENSP00000270460
- ENST00000411543
- ENSP00000406209
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
interacting protein | 0.89 | ||
disease perturbation | 0.87 | ||
transcription factor | 0.78 | ||
transcription factor binding site profile | 0.78 | ||
kinase perturbation | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.67 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 54.67 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (195)
EPN3
Novelty: 0.12685855
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.876
Data Source: BioPlex,STRINGDB
GAS2L1
Novelty: 0.17484834
p_int: 0.999990323
p_ni: 0.000009677
Score: 0.232
Data Source: BioPlex,STRINGDB
KIF20A
Novelty: 0.01640924
p_int: 0.999956127
p_ni: 0.000043868
p_wrong: 5e-9
Data Source: BioPlex
SLC2A14
Family: Transporter
Novelty: 0.00247741
p_int: 0.998045393
p_ni: 0.001954607
Score: 0.198
Data Source: BioPlex,STRINGDB
TADA2B
Family: TF
Novelty: 0.06387677
p_int: 0.997125753
p_ni: 0.002874024
p_wrong: 2.22e-7
Score: 0.185
Data Source: BioPlex,STRINGDB
RAB33B
Family: Enzyme
Novelty: 0.06381712
p_int: 0.991793495
p_ni: 0.008201103
p_wrong: 0.000005403
Data Source: BioPlex
FLVCR2
Novelty: 0.02871146
p_int: 0.98990895
p_ni: 0.01009064
p_wrong: 4.1e-7
Score: 0.382
Data Source: BioPlex,STRINGDB
PLPPR2
Family: Enzyme
Novelty: 1.03318406
p_int: 0.989005207
p_ni: 0.010994729
p_wrong: 6.4e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
AP2M1
Novelty: 0.00769368
p_int: 0.967025472
p_ni: 0.032193139
p_wrong: 0.000781389
Score: 0.964
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (13)
Reactome (8)
KEGG (1)
PathwayCommons (2)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | EGFR downregulation | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Signal Transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
EGFR downregulation | ||||
Membrane Trafficking | ||||
Signal Transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (1)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
age at menopause | 2 | 2 | 3 | 77.1 | |||||
triglyceride measurement | 3 | 2 | 3 | 72.7 | |||||
insomnia measurement | 1 | 2 | 0 | 1.1 | 56.3 | ||||
parental genotype effect measurement | 1 | 1 | 1 | 46.9 | |||||
birth weight | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
age at menopause | 3 | 77.1 | |||||
triglyceride measurement | 3 | 72.7 | |||||
insomnia measurement | 0 | 1.1 | 56.3 | ||||
parental genotype effect measurement | 1 | 46.9 | |||||
birth weight | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | epsin 1 | VGNC:2389 | 737301 | |||||
Macaque | epsin 1 | 702956 | ||||||
Mouse | MGI:1333763 | 13854 | ||||||
Rat | RGD:619772 | 117277 | ||||||
Dog | epsin 1 | VGNC:40419 | 608964 | |||||
Publication Statistics
PubMed Score 54.67
PubMed score by year
PubTator Score 28.73
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (10)
Items per page:
0 of 0
PMID | Year | Title |
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