EPHX2
Bifunctional epoxide hydrolase 2
Protein Summary
Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. A ...more
- ENST00000380476
- ENSP00000369843
- ENSG00000120915
- ENST00000521400
- ENSP00000430269
- ENST00000521780
- ENSP00000430302
- CEH
- SEH
- ABHD20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.97 | ||
transcription factor perturbation | 0.96 | ||
gene perturbation | 0.95 | ||
protein domain | 0.92 | ||
chemical | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230.17 (req: < 5)
Gene RIFs: 75 (req: <= 3)
Antibodies: 368 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 230.17 (req: >= 5)
Gene RIFs: 75 (req: > 3)
Antibodies: 368 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1561
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (6)
Active Ligands (1561)
Protein-Protein Interactions (137)
Nearest Tclin Targets (3)
Downstream (3)
1 – 3 of 3
Pathways (53)
Reactome (10)
KEGG (3)
WikiPathways (40)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biosynthesis of DHA-derived SPMs | ||||
Reactome | Biosynthesis of maresins | ||||
Reactome | Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Reactome | Fatty acid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Biosynthesis of DHA-derived SPMs | ||||
Biosynthesis of maresins | ||||
Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Fatty acid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Functions (8)
Components (4)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
smoking status measurement | 2 | 4 | 5 | 96.8 | |||||
smoking initiation | 4 | 5 | 5 | 94.8 | |||||
6 | 4 | 0 | 5.9 | 91.7 | |||||
family history of Alzheimer’s disease | 1 | 3 | 0 | 8.3 | 87.3 | ||||
cigarettes per day measurement | 4 | 4 | 5 | 77.2 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
smoking status measurement | 5 | 96.8 | |||||
smoking initiation | 5 | 94.8 | |||||
0 | 5.9 | 91.7 | |||||
family history of Alzheimer’s disease | 0 | 8.3 | 87.3 | ||||
cigarettes per day measurement | 5 | 77.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | epoxide hydrolase 2 | VGNC:11967 | 464074 | |||||
Macaque | epoxide hydrolase 2 | 712926 | ||||||
Mouse | MGI:99500 | 13850 | ||||||
Rat | RGD:620732 | 65030 | ||||||
Dog | epoxide hydrolase 2 | VGNC:40416 | 477373 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | epoxide hydrolase 2 | |||||
Macaque | epoxide hydrolase 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | epoxide hydrolase 2 | |||||
Publication Statistics
PubMed Score 230.17
PubMed score by year
PubTator Score 421.80
PubTator score by year
Related Publications
Text Mined References (130)
GeneRif Annotations (75)
Items per page:
0 of 0
PMID | Year | Title |
|---|