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Tchem
EPHX1
Epoxide hydrolase 1

Protein Summary
Description
Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water (By similarity). May play a role in the metabolism of endogenous lipids such as epoxide-containing fatty acids (PubMed:22798687). Epoxide hydrolase is a critical biotransformation enzyme that converts epoxides from the degradation of aromatic compounds to trans-dihydrodiols which can be conjugated and excreted from the body. Epoxide hydrolase functions in both the activation and detoxification of epoxides. Mutations in this gene cause preeclampsia, epoxide hydrolase deficiency or increased epoxide hydrolase activity. Alternatively spliced transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272167
  • ENSP00000272167
  • ENSG00000143819
  • ENST00000366837
  • ENSP00000355802
  • ENST00000614058
  • ENSP00000480004

Symbol
  • EPHX
  • EPOX
  • MEH
  • EPHX
  • EPOX
  • HYL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.97
gene perturbation
0.91
biological term
0.84
disease
0.84
disease perturbation
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.37   (req: < 5)
Gene RIFs: 166   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 521.37   (req: >= 5)
Gene RIFs: 166   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 197
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1