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Tchem
EPHB2
Ephrin type-B receptor 2

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobes of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. In addition to axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of developm ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374630
  • ENSP00000363761
  • ENSG00000133216
  • ENST00000374632
  • ENSP00000363763
  • ENST00000400191
  • ENSP00000383053

Symbol
  • DRT
  • EPHT3
  • EPTH3
  • ERK
  • HEK5
  • TYRO5
  • DRT
  • EK5
  • ERK
  • CAPB
  • Hek5
  • PCBC
  • EPHT3
  • Tyro5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
protein domain
1
molecular function
0.99
transcription factor perturbation
0.88
biological process
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 649.8   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 611   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 649.8   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 52
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3