Tchem EPHB1 Ephrin type-B receptor 1

Protein Summary

Description

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity). Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P54762
• A8K593
• B3KTB2
• B5A969
• O43569
• O95142
• O95143
• Q0VG87

Gene Name

• EPHB1

Ensembl ID

• ENST00000398015
• ENSP00000381097
• ENSG00000154928
• ENST00000493838
• ENSP00000419574

Symbol

• ELK
• EPHT2
• HEK6
• NET
• ELK
• NET
• Hek6
• EPHT2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
biological process	0.82
trait	0.75
transcription factor binding site profile	0.73

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Eph Family / Ephrin Type-b Receptor 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.89   (req: < 5)

Gene RIFs: 28   (req: <= 3)

Antibodies: 524   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.89   (req: >= 5)

Gene RIFs: 28   (req: > 3)

Antibodies: 524   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 36

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1

Expression Data (0 Tissues)

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No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (5)

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (1)

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dasatinib

EPHB1Tchem Kinase

INHIBITOR pKd : 7.89

Active Ligands (5)

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1 – 5 of 5

foretinib

EPHB1Tchem Kinase

pKd : 7.92

PD-173955

EPHB1Tchem Kinase

pKd : 7.92

CHEMBL566515

EPHB1Tchem Kinase

pIC50 : 9.04

compound 20 [PMID: 23489211]

EPHB1Tchem Kinase

pIC50 : 5.82

CHEMBL488840

EPHB1Tchem Kinase

pIC50 : 8.52

Protein-Protein Interactions (161)

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• See Interactions on String-DB

KLRG2

Tdark

Novelty:  1.19446694

p_int:  0.999996812

p_ni:  1.44e-7

p_wrong:  0.000003044

Score:  0.243

Data Source:  BioPlex,STRINGDB

EFNA5

Tbio

Novelty:  0.00134985

Score:  0.998

Data Source:  STRINGDB

EFNB2

Tbio

Novelty:  0.00255095

Score:  0.998

Data Source:  STRINGDB

EFNB1

Tbio

Novelty:  0.00523161

Score:  0.996

Data Source:  STRINGDB

EFNA1

Tbio

Family:  Kinase

Novelty:  0.00732252

Score:  0.995

Data Source:  STRINGDB

EFNB3

Tbio

Novelty:  0.0120367

Score:  0.993

Data Source:  STRINGDB

EFNA2

Tbio

Novelty:  0.01184859

Score:  0.993

Data Source:  STRINGDB

EFNA4

Tbio

Novelty:  0.03628159

Score:  0.992

Data Source:  STRINGDB

EFNA3

Tbio

Novelty:  0.01819539

Score:  0.992

Data Source:  STRINGDB

NCK1

Tbio

Novelty:  0.00352084

Score:  0.978

Data Source:  STRINGDB

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

ABL1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Axon guidance

Pathways (84)

Reactome (5)

KEGG (1)

PathwayCommons (5)

WikiPathways (73)

Axon guidance (R-HSA-422475)

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5

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665
Reactome	Ephrin signaling	19 targets	R-HSA-3928664

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665
Ephrin signaling	19 targets	R-HSA-3928664

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (51)

Functions (7)

Components (15)

Processes (29)

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1 – 7 of 7

GO Term	Evidence	Assigned by
protein tyrosine kinase activity	Inferred from Experiment (EXP)	Reactome
transmembrane-ephrin receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
transmembrane receptor protein tyrosine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transmembrane signaling receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
axon guidance receptor activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein-containing complex binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations (null)

No disease associations found

GWAS Traits (11)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	2	4	4		69.5
waist circumference	EFO_0004342	1	2	2		62
body height	EFO_0004339	1	1	1		35
mood instability measurement	EFO_0008475	1	1	1		21.5
BMI-adjusted hip circumference	EFO_0008039	1	1	1		17.8

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist circumference	EFO_0007789	4		69.5
waist circumference	EFO_0004342	2		62
body height	EFO_0004339	1		35
mood instability measurement	EFO_0008475	1		21.5
BMI-adjusted hip circumference	EFO_0008039	1		17.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
ATP-binding
Cell adhesion
Cell membrane
Cell projection
Complete proteome
Direct protein sequencing
Endosome
Glycoprotein

GWAS Trait Find Similar Targets

No Header	No Header
appendicular lean mass
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body height
disease progression measurement
high density lipoprotein cholesterol measurement
metastasis measurement
mood instability measurement
neuroticism measurement
sleep duration

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
nervous system phenotype
vision/eye phenotype

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	EPH receptor B1	VGNC:6219	460714
Mouse	Eph receptor B1	MGI:1096337	270190
Rat	Eph receptor B1	RGD:2556	24338
Dog	EPH receptor B1	VGNC:49889	485671
Opossum	EPH receptor B1		100023496

Species	Name	OMA	EggNOG	Inparanoid
Chimp	EPH receptor B1
Mouse	Eph receptor B1
Rat	Eph receptor B1
Dog	EPH receptor B1
Opossum	EPH receptor B1

Publication Statistics

PubMed Score 72.89

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PubTator Score 38.87

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Related Publications

Text Mined References (65)

GeneRif Annotations (28)

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PMID	Year	Title