Protein Summary
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formatio ...more
- ENST00000398015
- ENSP00000381097
- ENSG00000154928
- ENST00000493838
- ENSP00000419574
- ELK
- EPHT2
- HEK6
- NET
- ELK
- NET
- Hek6
- EPHT2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
biological process | 0.82 | ||
trait | 0.75 | ||
transcription factor binding site profile | 0.73 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.89 (req: < 5)
Gene RIFs: 28 (req: <= 3)
Antibodies: 524 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 72.89 (req: >= 5)
Gene RIFs: 28 (req: > 3)
Antibodies: 524 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 36
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (5)
Protein-Protein Interactions (161)
KLRG2
Novelty: 1.19446694
p_int: 0.999996812
p_ni: 1.44e-7
p_wrong: 0.000003044
Score: 0.243
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (84)
Reactome (5)
KEGG (1)
PathwayCommons (5)
WikiPathways (73)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | Ephrin signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Ephrin signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (51)
Functions (7)
Components (15)
Processes (29)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 2 | 4 | 4 | 69.5 | |||||
waist circumference | 1 | 2 | 2 | 62 | |||||
body height | 1 | 1 | 1 | 35 | |||||
mood instability measurement | 1 | 1 | 1 | 21.5 | |||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 17.8 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 4 | 69.5 | |||||
waist circumference | 2 | 62 | |||||
body height | 1 | 35 | |||||
mood instability measurement | 1 | 21.5 | |||||
BMI-adjusted hip circumference | 1 | 17.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor B1 | VGNC:6219 | 460714 | |||||
Mouse | MGI:1096337 | 270190 | ||||||
Rat | RGD:2556 | 24338 | ||||||
Dog | EPH receptor B1 | VGNC:49889 | 485671 | |||||
Opossum | EPH receptor B1 | 100023496 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor B1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor B1 | |||||
Opossum | EPH receptor B1 | |||||
Publication Statistics
PubMed Score 72.89
PubMed score by year
PubTator Score 38.87
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (65)
GeneRif Annotations (28)
Items per page:
0 of 0
PMID | Year | Title |
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