Tchem EPHA7 Ephrin type-A receptor 7

Protein Summary

Description

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Uniprot Accession IDs

• Q15375
• A0AUX7
• B2R8W1
• B7ZLJ9
• B7ZLK0
• Q59G40
• Q5VTU0
• Q8N368
• Q9H124

Gene Name

• EPHA7

Ensembl ID

• ENST00000369297
• ENSP00000358303
• ENSG00000135333
• ENST00000369303
• ENSP00000358309

Symbol

• EHK3
• HEK11
• EHK3
• EK11
• EHK-3
• HEK11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
molecular function	0.99
PubMedID	0.81
microRNA	0.79
trait	0.75

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Tk Group / Eph Family / Ephrin Type-a Receptor 7

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.87   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 488   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.87   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 488   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

ProKinO

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (9)

Explore Active Ligands

1 – 9 of 9

foretinib

EPHA7Tchem Kinase

pKd : 7.92

AT-9283

EPHA7Tchem Kinase

pKd : 7.92

OTS-167

EPHA7Tchem Kinase

pKd : 7.55

XL-228

EPHA7Tchem Kinase

pKd : 7.58

CHEMBL1784637

EPHA7Tchem Kinase

pIC50 : 9.7

CHEMBL566515

EPHA7Tchem Kinase

pIC50 : 9.04

DDR1/2 inhibitor 5n

EPHA7Tchem Kinase

pKd : 7.96

compound 20 [PMID: 23489211]

EPHA7Tchem Kinase

pIC50 : 5.82

Tesevatinib

EPHA7Tchem Kinase

pKd : 8.1

Protein-Protein Interactions (124)

Explore Interacting Targets

1 – 10 of 124

• See Interactions on String-DB

EPHA10

Tbio

Family:  Kinase

Novelty:  0.06416708

p_int:  1

Score:  0.935

Data Source:  BioPlex,STRINGDB

MBLAC2

Tdark

Family:  Enzyme

Novelty:  0.47407992

p_int:  0.999990485

p_ni:  0.000009515

Data Source:  BioPlex

PIK3IP1

Tbio

Family:  Enzyme

Novelty:  0.07364653

p_int:  0.999953049

p_ni:  0.000046951

Data Source:  BioPlex

EFNA5

Tbio

Novelty:  0.00134985

p_int:  0.999947839

p_ni:  0.000052161

Score:  0.998

Data Source:  BioPlex,STRINGDB

EPHA3

Tchem

Family:  Kinase

Novelty:  0.00466013

p_int:  0.999935474

p_ni:  0.000064479

p_wrong:  4.7e-8

Score:  0.933

Data Source:  BioPlex,STRINGDB

TMPRSS11B

Tdark

Family:  Enzyme

Novelty:  1.20690443

p_int:  0.999849893

p_ni:  0.000150107

Data Source:  BioPlex

BCAM

Tbio

Novelty:  0.01697541

p_int:  0.999419384

p_ni:  0.000580616

Data Source:  BioPlex

TMEM30B

Tbio

Novelty:  0.26735006

p_int:  0.99937945

p_ni:  0.00062055

Data Source:  BioPlex

PICK1

Tbio

Novelty:  0.0058265

p_int:  0.99902829

p_ni:  0.00097171

Score:  0.407

Data Source:  BioPlex,STRINGDB

TMX1

Tbio

Novelty:  0.03444237

p_int:  0.998889598

p_ni:  0.001110402

Score:  0.171

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets (1)

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Downstream (1)

1 – 1 of 1

ABL1

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Axon guidance

Pathways (7)

Reactome (4)

KEGG (1)

PathwayCommons (2)

Axon guidance (R-HSA-422475)

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5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	EPH-Ephrin signaling	92 targets	R-HSA-2682334
Reactome	EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Developmental Biology	1055 targets	R-HSA-1266738
EPH-Ephrin signaling	92 targets	R-HSA-2682334
EPH-ephrin mediated repulsion of cells	49 targets	R-HSA-3928665

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (42)

Functions (9)

Components (12)

Processes (21)

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Items per page:

10

1 – 9 of 9

GO Term	Evidence	Assigned by
transmembrane receptor protein tyrosine kinase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transmembrane signaling receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
transmembrane-ephrin receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
axon guidance receptor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
chemorepellent activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
GPI-linked ephrin receptor activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
protein tyrosine kinase activity	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
ephrin receptor binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3	2	3		73.4
cognitive function measurement	EFO_0008354	1	1	1		21.5
response to anticoagulant	GO_0061476	1	1	0	8.3	12.7
smoking status measurement	EFO_0006527	2	2	2		9.5
self reported educational attainment	EFO_0004784	1	1	1		7.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	3		73.4
cognitive function measurement	EFO_0008354	1		21.5
response to anticoagulant	GO_0061476	0	8.3	12.7
smoking status measurement	EFO_0006527	2		9.5
self reported educational attainment	EFO_0004784	1		7.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Apoptosis
ATP-binding
Cell membrane
Complete proteome
Developmental protein
Glycoprotein
Kinase
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
body height
cognitive function measurement
mathematical ability
response to anticoagulant
self reported educational attainment
smoking status measurement

MGI Phenotype Find Similar Targets

No Header	No Header
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	EPH receptor A7	VGNC:7175	472073
Macaque	EPH receptor A7		707295
Mouse	Eph receptor A7	MGI:95276	13841
Rat	Eph receptor A7	RGD:70957	171287
Dog	EPH receptor A7	VGNC:40409	474997

Species	Name	OMA	EggNOG	Inparanoid
Chimp	EPH receptor A7
Macaque	EPH receptor A7
Mouse	Eph receptor A7
Rat	Eph receptor A7
Dog	EPH receptor A7

Publication Statistics

PubMed Score 94.87

PubMed score by year

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PubTator Score 46.54

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Patents

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Related Publications

Text Mined References (50)

GeneRif Annotations (24)

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PMID	Year	Title