Protein Summary
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EP ...more
- ENST00000369297
- ENSP00000358303
- ENSG00000135333
- ENST00000369303
- ENSP00000358309
- EHK3
- HEK11
- EHK3
- EK11
- EHK-3
- HEK11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
PubMedID | 0.81 | ||
microRNA | 0.79 | ||
trait | 0.75 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.87 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 488 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 94.87 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 488 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 9
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (9)
Protein-Protein Interactions (124)
MBLAC2
Family: Enzyme
Novelty: 0.47407992
p_int: 0.999990485
p_ni: 0.000009515
Data Source: BioPlex
PIK3IP1
Family: Enzyme
Novelty: 0.07364653
p_int: 0.999953049
p_ni: 0.000046951
Data Source: BioPlex
EFNA5
Novelty: 0.00134985
p_int: 0.999947839
p_ni: 0.000052161
Score: 0.998
Data Source: BioPlex,STRINGDB
EPHA3
Family: Kinase
Novelty: 0.00466013
p_int: 0.999935474
p_ni: 0.000064479
p_wrong: 4.7e-8
Score: 0.933
Data Source: BioPlex,STRINGDB
TMPRSS11B
Family: Enzyme
Novelty: 1.20690443
p_int: 0.999849893
p_ni: 0.000150107
Data Source: BioPlex
PICK1
Novelty: 0.0058265
p_int: 0.99902829
p_ni: 0.00097171
Score: 0.407
Data Source: BioPlex,STRINGDB
TMX1
Novelty: 0.03444237
p_int: 0.998889598
p_ni: 0.001110402
Score: 0.171
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (7)
Reactome (4)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Viral Interactions (0)
Gene Ontology Terms (42)
Functions (9)
Components (12)
Processes (21)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 3 | 2 | 3 | 73.4 | |||||
cognitive function measurement | 1 | 1 | 1 | 21.5 | |||||
response to anticoagulant | 1 | 1 | 0 | 8.3 | 12.7 | ||||
smoking status measurement | 2 | 2 | 2 | 9.5 | |||||
self reported educational attainment | 1 | 1 | 1 | 7.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 3 | 73.4 | |||||
cognitive function measurement | 1 | 21.5 | |||||
response to anticoagulant | 0 | 8.3 | 12.7 | ||||
smoking status measurement | 2 | 9.5 | |||||
self reported educational attainment | 1 | 7.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor A7 | VGNC:7175 | 472073 | |||||
Macaque | EPH receptor A7 | 707295 | ||||||
Mouse | MGI:95276 | 13841 | ||||||
Rat | RGD:70957 | 171287 | ||||||
Dog | EPH receptor A7 | VGNC:40409 | 474997 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor A7 | |||||
Macaque | EPH receptor A7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor A7 | |||||
Publication Statistics
PubMed Score 94.87
PubMed score by year
PubTator Score 46.54
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (50)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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