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Tchem
EPHA5
Ephrin type-A receptor 5

Protein Summary
Description
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity). This gene belongs to th ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273854
  • ENSP00000273854
  • ENSG00000145242
  • ENST00000354839
  • ENSP00000346899

Symbol
  • BSK
  • EHK1
  • HEK7
  • TYRO4
  • EK7
  • CEK7
  • EHK1
  • HEK7
  • EHK-1
  • TYRO4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
kinase perturbation
0.81
microRNA
0.77
virus perturbation
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.43   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 487   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.43   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 487   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3