Protein Summary
Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous, it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3. Upon activation by ephrin ligands, modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac, Rap and Rho GTPases activity. Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections. May also control the segregation of motor and sensory axons during neuromuscular circuit development. I ...more
- ENST00000281821
- ENSP00000281821
- ENSG00000116106
- ENST00000409938
- ENSP00000386829
- HEK8
- SEK
- TYRO1
- EK8
- SEK
- HEK8
- TYRO1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
protein domain | 1 | ||
biological process | 0.97 | ||
PubMedID | 0.97 | ||
transcription factor perturbation | 0.96 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 361.98 (req: < 5)
Gene RIFs: 41 (req: <= 3)
Antibodies: 635 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 361.98 (req: >= 5)
Gene RIFs: 41 (req: > 3)
Antibodies: 635 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 48
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (15)
Protein-Protein Interactions (184)
EFNA5
Novelty: 0.00134985
p_int: 0.999418723
p_ni: 0.000581277
Score: 0.999
Data Source: BioPlex,STRINGDB
IARS2
Family: Enzyme
Novelty: 0.00854621
p_int: 0.99924068
p_ni: 0.00075932
Data Source: BioPlex
CALML3
Novelty: 0.0336689
p_int: 0.99884891
p_ni: 0.001151028
p_wrong: 6.3e-8
Data Source: BioPlex
COPZ1
Novelty: 0.01405958
p_int: 0.998231872
p_ni: 0.001768128
p_wrong: 1e-9
Data Source: BioPlex
RSPH14
Novelty: 0.53463266
p_int: 0.99772695
p_ni: 0.00227305
Score: 0.199
Data Source: BioPlex,STRINGDB
TBC1D22A
Novelty: 0.46374046
p_int: 0.992244291
p_ni: 0.007755709
Score: 0.154
Data Source: BioPlex,STRINGDB
CTLA4
Novelty: 0.00012781
p_int: 0.987411446
p_ni: 0.012588513
p_wrong: 4e-8
Data Source: BioPlex
TUBB
Novelty: 0.0038007
p_int: 0.98695319
p_ni: 0.01304681
Score: 0.158
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (11)
Reactome (4)
KEGG (1)
PathwayCommons (3)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
Viral Interactions (0)
Gene Ontology Terms (73)
Functions (13)
Components (25)
Processes (35)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Genetic Interaction (IGI) | ARUK-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | ARUK-UCL | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 1 | 2 | 64.4 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 64.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor A4 | VGNC:10781 | 470660 | |||||
Macaque | EPH receptor A4 | 704857 | ||||||
Mouse | MGI:98277 | 13838 | ||||||
Rat | RGD:1560587 | 316539 | ||||||
Dog | EPH receptor A4 | VGNC:40407 | 478925 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor A4 | |||||
Macaque | EPH receptor A4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor A4 | |||||
Publication Statistics
PubMed Score 361.98
PubMed score by year
PubTator Score 116.72
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (76)
GeneRif Annotations (41)
Items per page:
0 of 0
PMID | Year | Title |
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