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Tbio
EPHA10
Ephrin type-A receptor 10

Protein Summary
Description
Receptor for members of the ephrin-A family. Binds to EFNA3, EFNA4 and EFNA5. Ephrin receptors, the largest subfamily of receptor tyrosine kinases (RTKs), and their ephrin ligands are important mediators of cell-cell communication regulating cell attachment, shape, and mobility in neuronal and epithelial cells (Aasheim et al., 2005 [PubMed 15777695]). See MIM 179610 for additional background on Eph receptors and ephrins.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319637
  • ENSP00000316395
  • ENSG00000183317
  • ENST00000373048
  • ENSP00000362139
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.98
microRNA
0.83
tissue sample
0.67
cellular component
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.79   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.79   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  1
Score:  0.935
Data Source:  BioPlex,STRINGDB
EFNB1
Tbio
Novelty:  0.00523161
Score:  0.993
Data Source:  STRINGDB
EFNA2
Tbio
Novelty:  0.01184859
Score:  0.992
Data Source:  STRINGDB
EFNA4
Tbio
Novelty:  0.03628159
Score:  0.992
Data Source:  STRINGDB
EFNA5
Tbio
Novelty:  0.00134985
Score:  0.992
Data Source:  STRINGDB
EFNA1
Tbio
Family:  Kinase
Novelty:  0.00732252
Score:  0.992
Data Source:  STRINGDB
EFNB3
Tbio
Novelty:  0.0120367
Score:  0.992
Data Source:  STRINGDB
EFNB2
Tbio
Novelty:  0.00255095
Score:  0.992
Data Source:  STRINGDB
EFNA3
Tbio
Novelty:  0.01819539
Score:  0.992
Data Source:  STRINGDB
ADAM10
Tchem
Family:  Enzyme
Novelty:  0.00160129
Score:  0.912
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPH-ephrin mediated repulsion of cells
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
EPH-Ephrin signaling
EPH-ephrin mediated repulsion of cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
1
4
87.2
2
1
2
1.1
53.7
intraocular pressure measurement
2
1
2
53.3
mathematical ability
3
2
3
53.2
1
1
0
1.1
50.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
4
87.2
2
1.1
53.7
intraocular pressure measurement
2
53.3
mathematical ability
3
53.2
0
1.1
50.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A10
VGNC:52939
469284
Mouse
MGI:3586824
230735
Rat
RGD:1562679
298528
Dog
EPH receptor A10 [Source:HGNC Symbol;Acc:HGNC:19987]
Horse
EPH receptor A10
VGNC:50689
100069107
Species
Name
OMA
EggNOG
Inparanoid
Chimp
EPH receptor A10
Mouse
Rat
Dog
EPH receptor A10 [Source:HGNC Symbol;Acc:HGNC:19987]
Horse
EPH receptor A10
Publication Statistics
PubMed Score 18.79
PubMed score by year
PubTator Score 12.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title