Protein Summary
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis. This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Rec ...more
- ENST00000275815
- ENSP00000275815
- ENSG00000146904
- ENST00000645847
- ENSP00000494931
- ENSG00000284816
- EPH
- EPHT
- EPHT1
- EPH
- EPHT
- EPHT1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
protein domain | 1 | ||
molecular function | 0.99 | ||
biological process | 0.88 | ||
PubMedID | 0.84 | ||
kinase perturbation | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 660.75 (req: < 5)
Gene RIFs: 39 (req: <= 3)
Antibodies: 539 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 660.75 (req: >= 5)
Gene RIFs: 39 (req: > 3)
Antibodies: 539 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 10
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (10)
Protein-Protein Interactions (226)
SMG1
Family: Kinase
Novelty: 0.00854339
p_int: 0.999999799
p_ni: 2.01e-7
Score: 0.277
Data Source: BioPlex,STRINGDB
RELCH
Novelty: 0.33696386
p_int: 0.9999997
p_ni: 2.99e-7
Score: 0.162
Data Source: BioPlex,STRINGDB
USP34
Family: Enzyme
Novelty: 0.16444192
p_int: 0.999997791
p_ni: 0.000002209
Score: 0.159
Data Source: BioPlex,STRINGDB
SMG9
Novelty: 0.03940774
p_int: 0.999987991
p_ni: 5.3e-7
p_wrong: 0.000011479
Score: 0.187
Data Source: BioPlex,STRINGDB
FAM114A2
Novelty: 0.40545319
p_int: 0.999981741
p_ni: 0.00001824
p_wrong: 1.9e-8
Data Source: BioPlex
DYNC2H1
Novelty: 0.01306616
p_int: 0.999980059
p_ni: 0.000019941
Score: 0.188
Data Source: BioPlex,STRINGDB
DIAPH3
Novelty: 0.01165283
p_int: 0.99997974
p_ni: 0.00002026
Score: 0.159
Data Source: BioPlex,STRINGDB
KIF14
Novelty: 0.02313641
p_int: 0.999976879
p_ni: 0.000023121
Score: 0.257
Data Source: BioPlex,STRINGDB
WDR13
Novelty: 0.05397678
p_int: 0.999973179
p_ni: 0.000001948
p_wrong: 0.000024873
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (9)
Reactome (6)
KEGG (1)
PathwayCommons (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Axon guidance | ||||
Reactome | Developmental Biology | ||||
Reactome | EPH-Ephrin signaling | ||||
Reactome | EPH-ephrin mediated repulsion of cells | ||||
Reactome | POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Axon guidance | ||||
Developmental Biology | ||||
EPH-Ephrin signaling | ||||
EPH-ephrin mediated repulsion of cells | ||||
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (6)
Components (5)
Processes (20)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 89.2 | ||||||
serum gamma-glutamyl transferase measurement | 2 | 2 | 2 | 89.2 | ||||||
basophil count | 3 | 1 | 3 | 85.2 | ||||||
basophil count | 3 | 1 | 3 | 85.2 | ||||||
basophil percentage of leukocytes | 1 | 1 | 1 | 84.9 | ||||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
serum gamma-glutamyl transferase measurement | 2 | 89.2 | |||||
serum gamma-glutamyl transferase measurement | 2 | 89.2 | |||||
basophil count | 3 | 85.2 | |||||
basophil count | 3 | 85.2 | |||||
basophil percentage of leukocytes | 1 | 84.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | EPH receptor A1 | VGNC:14442 | 463808 | |||||
Mouse | MGI:107381 | 13835 | ||||||
Rat | RGD:1304680 | 312279 | ||||||
Dog | EPH receptor A1 | VGNC:40404 | 482735 | |||||
Horse | EPH receptor A1 | VGNC:17616 | 100056221 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | EPH receptor A1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | EPH receptor A1 | |||||
Horse | EPH receptor A1 | |||||
Publication Statistics
PubMed Score 660.75
PubMed score by year
PubTator Score 135.90
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (61)
GeneRif Annotations (39)
Items per page:
0 of 0
PMID | Year | Title |
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