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Tbio
EPDR1
Mammalian ependymin-related protein 1

Protein Summary
Description
The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000199448
  • ENSP00000199448
  • ENSG00000086289
  • ENST00000423717
  • ENSP00000409211
  • ENST00000425345
  • ENSP00000413359

Symbol
  • MERP1
  • UCC1
  • EPDR
  • UCC1
  • MERP1
  • MERP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
interacting protein
0.73
microRNA
0.63
cellular component
0.54
small molecule perturbation
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.48   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.48   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
RUNDC3A
Tdark
Novelty:  0.23296904
p_int:  0.99998977
p_ni:  0.00001023
p_wrong:  1e-9
Data Source:  BioPlex
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.999979353
p_ni:  0.000020647
Data Source:  BioPlex
GRB14
Tbio
Novelty:  0.02565119
p_int:  0.99996126
p_ni:  0.000038736
p_wrong:  4e-9
Data Source:  BioPlex
MRPS34
Tbio
Novelty:  0.29355603
p_int:  0.999945999
p_ni:  0.000053894
p_wrong:  1.06e-7
Data Source:  BioPlex
TSHB
Tbio
Novelty:  0.00194403
p_int:  0.999900394
p_ni:  0.000099355
p_wrong:  2.51e-7
Score:  0.532
Data Source:  BioPlex,STRINGDB
PCDHGC5
Tdark
Novelty:  0.39651826
p_int:  0.999896141
p_ni:  0.000103845
p_wrong:  1.4e-8
Data Source:  BioPlex
ARF5
Tbio
Family:  Enzyme
Novelty:  0.02454098
p_int:  0.99989002
p_ni:  0.000109953
p_wrong:  2.6e-8
Data Source:  BioPlex
ENPP7
Tbio
Family:  Enzyme
Novelty:  0.01963359
p_int:  0.999850481
p_ni:  0.000147085
p_wrong:  0.000002434
Score:  0.189
Data Source:  BioPlex,STRINGDB
TINAG
Tbio
Novelty:  0.04582927
p_int:  0.999791095
p_ni:  0.000208874
p_wrong:  3.1e-8
Score:  0.312
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.998985569
p_ni:  0.000859557
p_wrong:  0.000154875
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
9
13
99.3
Dupuytren Contracture
2
2
0
1.9
94.6
bone density
2
2
2
68.4
1
1
0
1.2
63.1
1
1
0
1.1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
13
99.3
Dupuytren Contracture
0
1.9
94.6
bone density
2
68.4
0
1.2
63.1
0
1.1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2145369
105298
Rat
RGD:1359161
291180
Cow
ependymin related 1
VGNC:28530
615376
Chicken
ependymin related 1
CGNC:9150
420731
Anole lizard
ependymin related 1
100559471
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
ependymin related 1
Chicken
ependymin related 1
Anole lizard
ependymin related 1
Publication Statistics
PubMed Score 34.48
PubMed score by year
PubTator Score 12.46
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title