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Tbio
EPC2
Enhancer of polycomb homolog 2

Protein Summary
Description
May play a role in transcription or DNA repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258484
  • ENSP00000258484
  • ENSG00000135999

Symbol
  • EPC-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
transcription factor binding site profile
0.87
kinase perturbation
0.81
cell line
0.64
cell type or tissue
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.15   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 52.15   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (80)
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999999465
p_ni:  5.35e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999999306
p_ni:  6.94e-7
Score:  0.283
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.99999887
p_ni:  0.00000113
Score:  0.703
Data Source:  BioPlex,STRINGDB
MBTD1
Tbio
Family:  Epigenetic
Novelty:  0.11651052
p_int:  0.999998372
p_ni:  0.000001626
p_wrong:  2e-9
Score:  0.28
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.99999829
p_ni:  0.00000171
Score:  0.724
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999997561
p_ni:  0.000002439
Score:  0.938
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999995435
p_ni:  0.000004565
Score:  0.906
Data Source:  BioPlex,STRINGDB
FOXR1
Tbio
Family:  TF
Novelty:  0.20300395
p_int:  0.999993165
p_ni:  0.000006835
Score:  0.822
Data Source:  BioPlex,STRINGDB
EP400
Tbio
Novelty:  0.02013098
p_int:  0.999979087
p_ni:  0.000020913
Score:  0.781
Data Source:  BioPlex,STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
p_int:  0.999968567
p_ni:  0.000031434
Score:  0.96
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
4
4
2
1.1
71
educational attainment
1
1
1
46
schizophrenia
2
2
0
1.1
44
heel bone mineral density
1
1
1
3.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
2
1.1
71
educational attainment
1
46
schizophrenia
0
1.1
44
heel bone mineral density
1
3.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of polycomb homolog 2
470713
Macaque
enhancer of polycomb homolog 2
721916
Mouse
MGI:1278321
227867
Rat
RGD:1307271
362132
Dog
enhancer of polycomb homolog 2
VGNC:40401
476143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of polycomb homolog 2
Macaque
enhancer of polycomb homolog 2
Mouse
Rat
Dog
enhancer of polycomb homolog 2
Publication Statistics
PubMed Score 52.15
PubMed score by year
PubTator Score 13.34
PubTator score by year
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Related Publications
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PMID
Year
Title