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Tbio
EPC1
Enhancer of polycomb homolog 1

Protein Summary
Description
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. This gene encodes a member of the polycomb group (PcG) family. The encoded protein is a component of the NuA4 histone acetyltransferase complex and can act as both a transcriptional activator and repressor. The encoded protein has been linked to apoptosis, DNA repair, skeletal muscle differentiation, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263062
  • ENSP00000263062
  • ENSG00000120616
  • ENST00000319778
  • ENSP00000318559
  • ENST00000375110
  • ENSP00000364251

Symbol
  • Epl1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor binding site profile
0.97
disease perturbation
0.87
hub protein
0.82
cell type or tissue
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.73   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.73   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
FOXR2
Tbio
Family:  TF
Novelty:  0.06548862
p_int:  0.999999679
p_ni:  3.21e-7
Score:  0.699
Data Source:  BioPlex,STRINGDB
RUVBL1
Tbio
Novelty:  0.0089115
p_int:  0.999999643
p_ni:  3.57e-7
Score:  0.983
Data Source:  BioPlex,STRINGDB
MYCL
Tbio
Family:  TF
Novelty:  0.0034508
p_int:  0.999999269
p_ni:  7.31e-7
Score:  0.72
Data Source:  BioPlex,STRINGDB
DMAP1
Tbio
Family:  Enzyme
Novelty:  0.03152166
p_int:  0.999997877
p_ni:  0.00000212
p_wrong:  3e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
p_int:  0.999997868
p_ni:  0.00000213
p_wrong:  2e-9
Score:  0.482
Data Source:  BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999997291
p_ni:  0.000002709
Score:  0.703
Data Source:  BioPlex,STRINGDB
MEAF6
Tbio
Novelty:  0.0914094
p_int:  0.999997158
p_ni:  0.000002841
p_wrong:  1e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
RUVBL2
Tbio
Novelty:  0.01129017
p_int:  0.999994611
p_ni:  0.000005389
Score:  0.976
Data Source:  BioPlex,STRINGDB
FOXR1
Tbio
Family:  TF
Novelty:  0.20300395
p_int:  0.999993513
p_ni:  0.000006487
Score:  0.822
Data Source:  BioPlex,STRINGDB
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999992143
p_ni:  0.000007857
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HATs acetylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HATs acetylate histones
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
2
3
83
balding measurement
1
1
1
76.6
diastolic blood pressure
1
1
1
37.6
waist-hip ratio
1
1
1
14.2
mean platelet volume
1
1
1
13
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
3
83
balding measurement
1
76.6
diastolic blood pressure
1
37.6
waist-hip ratio
1
14.2
mean platelet volume
1
13
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
enhancer of polycomb homolog 1
VGNC:7276
450393
Macaque
enhancer of polycomb homolog 1
702805
Mouse
MGI:1278322
13831
Rat
RGD:2324280
100362678
Dog
enhancer of polycomb homolog 1
VGNC:40400
477970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
enhancer of polycomb homolog 1
Macaque
enhancer of polycomb homolog 1
Mouse
Rat
Dog
enhancer of polycomb homolog 1
Publication Statistics
PubMed Score 34.73
PubMed score by year
PubTator Score 30.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title