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Tbio
EPB41L4B
Band 4.1-like protein 4B

Protein Summary
Description
Up-regulates the activity of the Rho guanine nucleotide exchange factor ARHGEF18 (By similarity). Involved in the regulation of the circumferential actomyosin belt in epithelial cells (PubMed:22006950). Promotes cellular adhesion, migration and motility in vitro and may play a role in wound healing (PubMed:23664528). May have a role in mediating cytoskeletal changes associated with steroid-induced cell differentiation (PubMed:14521927).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374557
  • ENSP00000363685
  • ENSG00000095203
  • ENST00000374566
  • ENSP00000363694

Symbol
  • EHM2
  • LULU2
  • CG1
  • EHM2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.94
virus perturbation
0.94
gene perturbation
0.78
transcription factor binding site profile
0.77


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
CASQ2
Tbio
Novelty:  0.00775794
p_int:  0.99998698
p_ni:  0.000012814
p_wrong:  2.06e-7
Score:  0.204
Data Source:  BioPlex,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.914811165
p_ni:  0.000059155
p_wrong:  0.08512968
Score:  0.188
Data Source:  BioPlex,STRINGDB
ARHGEF18
Tbio
Novelty:  0.06684082
Score:  0.81
Data Source:  STRINGDB
TAAR1
Tclin
Family:  GPCR
Novelty:  0.0018424
Score:  0.807
Data Source:  STRINGDB
SCNN1G
Tclin
Family:  IC
Novelty:  0.00689941
Score:  0.72
Data Source:  STRINGDB
RPRD1A
Tbio
Novelty:  0.13521196
Score:  0.647
Data Source:  STRINGDB
ESR2
Tclin
Family:  NR
Novelty:  0.0002362
Score:  0.63
Data Source:  STRINGDB
MPP5
Tbio
Novelty:  0.01707773
Score:  0.618
Data Source:  STRINGDB
ARG2
Tchem
Family:  Enzyme
Novelty:  0.0006655
Score:  0.603
Data Source:  STRINGDB
NAA38
Tdark
Family:  Enzyme
Novelty:  19.36506889
Score:  0.582
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
2
3
75.7
2
2
2
50.5
cognitive function measurement
3
1
3
49.5
serum alanine aminotransferase measurement
2
1
1
6.5
46.1
BMI-adjusted waist-hip ratio
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
75.7
2
50.5
cognitive function measurement
3
49.5
serum alanine aminotransferase measurement
1
6.5
46.1
BMI-adjusted waist-hip ratio
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859149
54357
Dog
erythrocyte membrane protein band 4.1 like 4B
VGNC:40397
474797
Horse
erythrocyte membrane protein band 4.1 like 4B
VGNC:17611
100059009
Cow
erythrocyte membrane protein band 4.1 like 4B
VGNC:28524
519310
Opossum
erythrocyte membrane protein band 4.1 like 4B
100014652
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
erythrocyte membrane protein band 4.1 like 4B
Horse
erythrocyte membrane protein band 4.1 like 4B
Cow
erythrocyte membrane protein band 4.1 like 4B
Opossum
erythrocyte membrane protein band 4.1 like 4B
Publication Statistics
PubMed Score 10.34
PubMed score by year
PubTator Score 10.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title