Tbio EOMES Eomesodermin homolog

Protein Summary

Description

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013]

Uniprot Accession IDs

• O95936
• B7Z4I2
• B7ZA51
• G3XAI5
• Q8TAZ2
• Q9UPM7

Gene Name

• EOMES

Ensembl ID

• ENST00000295743
• ENSP00000295743
• ENSG00000163508
• ENST00000449599
• ENSP00000388620
• ENST00000461503
• ENSP00000487112

Symbol

• TBR2
• TBR2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.95
molecular function	0.86
transcription factor binding site profile	0.76
gene perturbation	0.75
PubMedID	0.71

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Eomesodermin Homolog

Protein / Nucleic Acid Binding / Eomesodermin Homolog

Protein / ... / Rel Homology Transcription Factor / Eomesodermin Homolog

DTO Classes

Protein / Transcription Factor / Immunoglobulin Fold Transcription Factor / Rel Homology Transcription Factor / Eomesodermin Homolog

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.66   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 414   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 444.66   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0