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Tbio
EOMES
Eomesodermin homolog

Protein Summary
Description
Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes. This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during tro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295743
  • ENSP00000295743
  • ENSG00000163508
  • ENST00000449599
  • ENSP00000388620
  • ENST00000461503
  • ENSP00000487112

Symbol
  • TBR2
  • TBR2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.86
transcription factor binding site profile
0.76
gene perturbation
0.75
PubMedID
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.7   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.7   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (195)
PAX6
Tbio
Family:  TF
Novelty:  0.00064695
Score:  0.903
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.845
Data Source:  STRINGDB
GZMB
Tchem
Family:  Enzyme
Novelty:  0.00052869
Score:  0.829
Data Source:  STRINGDB
PRF1
Tchem
Novelty:  0.0002835
Score:  0.825
Data Source:  STRINGDB
IL2RB
Tclin
Novelty:  0.0050905
Score:  0.815
Data Source:  STRINGDB
GATA3
Tbio
Family:  TF
Novelty:  0.00071141
Score:  0.811
Data Source:  STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.806
Data Source:  STRINGDB
IL4
Tbio
Novelty:  0.00005852
Score:  0.806
Data Source:  STRINGDB
IL2
Tchem
Novelty:  0.00003129
Score:  0.789
Data Source:  STRINGDB
MIXL1
Tbio
Family:  TF
Novelty:  0.0196256
Score:  0.783
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence Model (ISM)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
81.4
3
3
0
1.1
78.9
myeloid white cell count
1
1
1
39.6
leukocyte count
1
1
1
34.8
HbA1c measurement
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
81.4
0
1.1
78.9
myeloid white cell count
1
39.6
leukocyte count
1
34.8
HbA1c measurement
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
eomesodermin
VGNC:1808
470774
Mouse
MGI:1201683
13813
Dog
eomesodermin
VGNC:40389
485636
Horse
eomesodermin
VGNC:17604
100051187
Cow
eomesodermin
VGNC:28516
511947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
eomesodermin
Mouse
Dog
eomesodermin
Horse
eomesodermin
Cow
eomesodermin
Publication Statistics
PubMed Score 369.70
PubMed score by year
PubTator Score 88.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title