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Tbio
ENTPD7
Ectonucleoside triphosphate diphosphohydrolase 7

Protein Summary
Description
Preferentially hydrolyzes nucleoside 5'-triphosphates. The order of activity with respect to possible substrates is UTP > GTP > CTP. This gene encodes a purine-converting ectoenzyme which belongs to the ecto-nucleoside triphosphate diphosphohydrolase (E-NTPDase) family. The encoded protein hydrolyzes extracellular nucleoside triphosphates (UTP, GTP, and CTP) to nucleoside monophosphates as part of a purinergic signaling pathway. It contains two transmembrane domains at the N- and C-termini and a large, hydrophobic catalytic domain located in between. This gene affects oxidative stress as well as DNA damage and is a mediator of senescence. [provided by RefSeq, Mar 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370489
  • ENSP00000359520
  • ENSG00000198018

Symbol
  • LALP1
  • LALP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
histone modification site profile
0.87
kinase perturbation
0.76
virus perturbation
0.76
microRNA
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.54   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (38)
TEX264
Tbio
Novelty:  0.32406417
p_int:  0.999897782
p_ni:  0.000102218
Data Source:  BioPlex
SPPL2B
Tchem
Family:  Enzyme
Novelty:  0.0274774
p_int:  0.999188219
p_ni:  0.000811781
p_wrong:  1e-9
Data Source:  BioPlex
USP32
Tbio
Family:  Enzyme
Novelty:  0.08043957
p_int:  0.998255015
p_ni:  0.001744985
Score:  0.224
Data Source:  BioPlex,STRINGDB
P10314
Tbio
Novelty:  0.00270731
p_int:  0.998167357
p_ni:  0.001832643
Data Source:  BioPlex
SYT12
Tbio
Novelty:  0.03410873
p_int:  0.99738597
p_ni:  0.001322127
p_wrong:  0.001291902
Data Source:  BioPlex
ATP1B4
Tdark
Family:  Transporter
Novelty:  0.08212894
p_int:  0.991359368
p_ni:  0.008070139
p_wrong:  0.000570492
Data Source:  BioPlex
ATP2B2
Tbio
Family:  Transporter
Novelty:  0.007782
p_int:  0.985739105
p_ni:  0.014260895
Data Source:  BioPlex
CD1E
Tbio
Novelty:  0.00171622
p_int:  0.979685428
p_ni:  0.01468404
p_wrong:  0.005630533
Data Source:  BioPlex
CHRNA3
Tclin
Family:  IC
Novelty:  0.00659767
p_int:  0.978078545
p_ni:  0.020100137
p_wrong:  0.001821318
Data Source:  BioPlex
TCTN2
Tbio
Novelty:  0.11617528
p_int:  0.976381645
p_ni:  0.022923257
p_wrong:  0.000695098
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NTPDase proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NTPDase proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
92.3
serum gamma-glutamyl transferase measurement
1
2
2
63.8
serum alanine aminotransferase measurement
1
1
1
36.9
bilirubin measurement
1
1
1
35.6
1
1
0
1.1
18.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.3
serum gamma-glutamyl transferase measurement
2
63.8
serum alanine aminotransferase measurement
1
36.9
bilirubin measurement
1
35.6
0
1.1
18.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 7
VGNC:3842
450668
Macaque
ectonucleoside triphosphate diphosphohydrolase 7
708844
Mouse
MGI:2135885
93685
Dog
ectonucleoside triphosphate diphosphohydrolase 7
VGNC:40385
608065
Horse
ectonucleoside triphosphate diphosphohydrolase 7
VGNC:17600
100060757
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 7
Macaque
ectonucleoside triphosphate diphosphohydrolase 7
Mouse
Dog
ectonucleoside triphosphate diphosphohydrolase 7
Horse
ectonucleoside triphosphate diphosphohydrolase 7
Publication Statistics
PubMed Score 8.54
PubMed score by year
PubTator Score 3.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title