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Tbio
ENTPD4
Ectonucleoside triphosphate diphosphohydrolase 4

Protein Summary
Description
Hydrolyzes preferentially nucleoside 5'-diphosphates, nucleoside 5'-triphosphates are hydrolyzed only to a minor extent. The order of activity with different substrates is UDP >> GDP = CDP = TDP, AMP, ADP, ATP and UMP are not substrates. Preferred substrates for isoform 2 are CTP, UDP, CDP, GTP and GDP, while isoform 1 utilizes UTP and TTP. This gene encodes a member of the apyrase protein family. Apyrases are enzymes that catalyze the hydrolysis of nucleotide diphosphates and triphosphates in a calcium or magnesium-dependent manner. The encoded protein is an endo-apyrase and may play a role in salvaging nucleotides from lysosomes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and these isoforms may differ in divalent cation dependence and substrate specificity. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358689
  • ENSP00000351520
  • ENSG00000197217
  • ENST00000417069
  • ENSP00000408573

Symbol
  • KIAA0392
  • LALP70
  • LYSAL1
  • LAP70
  • LALP70
  • LYSAL1
  • UDPase
  • NTPDase-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.97
transcription factor perturbation
0.94
kinase perturbation
0.88
virus perturbation
0.83
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
PCYOX1
Tbio
Family:  Enzyme
Novelty:  0.18505748
p_int:  0.999918611
p_ni:  0.000081389
Score:  0.188
Data Source:  BioPlex,STRINGDB
CD79B
Tclin
Novelty:  0.00227414
p_int:  0.999687343
p_ni:  0.000268796
p_wrong:  0.000043861
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.999529663
p_ni:  0.000248331
p_wrong:  0.000222005
Data Source:  BioPlex
ATP2A3
Tchem
Family:  Transporter
Novelty:  0.0090982
p_int:  0.991193675
p_ni:  0.008806325
Score:  0.18
Data Source:  BioPlex,STRINGDB
TYW1B
Tdark
Family:  Enzyme
Novelty:  0.86504466
p_int:  0.98224343
p_ni:  0.017568669
p_wrong:  0.000187902
Score:  0.204
Data Source:  BioPlex,STRINGDB
GABRE
Tclin
Family:  IC
Novelty:  0.03814541
p_int:  0.977945277
p_ni:  0.000160259
p_wrong:  0.021894465
Score:  0.197
Data Source:  BioPlex,STRINGDB
HFE
Tbio
Novelty:  0.00042077
p_int:  0.969536611
p_ni:  0.005058101
p_wrong:  0.025405288
Data Source:  BioPlex
SCN3B
Tbio
Family:  IC
Novelty:  0.0438123
p_int:  0.927078866
p_ni:  0.000296302
p_wrong:  0.072624832
Data Source:  BioPlex
PDZD8
Tbio
Novelty:  0.09015543
p_int:  0.878159997
p_ni:  0.121840003
Score:  0.183
Data Source:  BioPlex,STRINGDB
ADSSL1
Tbio
Family:  Enzyme
Novelty:  0.0511949
Score:  0.953
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
1 – 5 of 14
PDE3B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6D
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE1C
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE6B
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
PDE2A
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (10)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NTPDase proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NTPDase proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
86.1
testosterone measurement
5
2
4
6
84.7
red blood cell distribution width
3
2
4
84.3
body height
1
2
2
79.9
central corneal thickness
2
2
0
2.1
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
86.1
testosterone measurement
4
6
84.7
red blood cell distribution width
4
84.3
body height
2
79.9
central corneal thickness
0
2.1
76.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 4
VGNC:881
464056
Macaque
ectonucleoside triphosphate diphosphohydrolase 4 [Source:RefSeq peptide;Acc:NP_001248494]
Mouse
MGI:1914714
67464
Dog
ectonucleoside triphosphate diphosphohydrolase 4
VGNC:40383
486117
Horse
ectonucleoside triphosphate diphosphohydrolase 4
VGNC:17598
100053982
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ectonucleoside triphosphate diphosphohydrolase 4
Macaque
ectonucleoside triphosphate diphosphohydrolase 4 [Source:RefSeq peptide;Acc:NP_001248494]
Mouse
Dog
ectonucleoside triphosphate diphosphohydrolase 4
Horse
ectonucleoside triphosphate diphosphohydrolase 4
Publication Statistics
PubMed Score 13.00
PubMed score by year
PubTator Score 13.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title