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Tbio
U2AF1
Splicing factor U2AF 35 kDa subunit

Protein Summary
Description
Plays a critical role in both constitutive and enhancer-dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291552
  • ENSP00000291552
  • ENSG00000160201
  • ENST00000380276
  • ENSP00000369629
  • ENST00000398137
  • ENSP00000381205
  • ENST00000459639
  • ENSP00000418705
  • ENST00000464750
  • ENSP00000420672

Symbol
  • U2AF35
  • U2AFBP
  • RN
  • FP793
  • U2AF35
  • U2AFBP
  • RNU2AF1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.42   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.42   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (151)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
RNA Polymerase II Transcription
Reactome
RNA Polymerase II Transcription Termination
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
RNA Polymerase II Transcription
RNA Polymerase II Transcription Termination
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (201)
1 – 10 of 201
U2AF2
Tbio
Novelty: 0.00739606
p_int: 0.999999834
p_ni: 1.66e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
SCAF11
Tdark
Novelty: 0.01139854
p_int: 0.999999224
p_ni: 7.76e-7
Score: 0.535
Data Source: BioPlex,STRINGDB
SRPK2
Tchem
Family: Kinase
Novelty: 0.00800453
p_int: 0.999632666
p_ni: 0.000367334
Score: 0.588
Data Source: BioPlex,STRINGDB
SRPK1
Tchem
Family: Kinase
Novelty: 0.01209944
p_int: 0.999138306
p_ni: 0.000861694
Score: 0.677
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00134844
p_int: 0.997739329
p_ni: 0.002260671
Score: 0.523
Data Source: BioPlex,STRINGDB
U2AF1L4
Tbio
Novelty: 0.03744272
p_int: 0.993841336
p_wrong: 0.006158664
Score: 0.817
Data Source: BioPlex,STRINGDB
CARNMT1
Tbio
Family: Enzyme
Novelty: 0.3423913
p_int: 0.989623569
p_ni: 0.010376431
Data Source: BioPlex
ACIN1
Tbio
Novelty: 0.00112465
p_int: 0.988354671
p_ni: 0.011645328
p_wrong: 1e-9
Score: 0.363
Data Source: BioPlex,STRINGDB
GSK3B
Tclin
Family: Kinase
Novelty: 0.00104435
p_int: 0.855139025
p_ni: 0.14486097
p_wrong: 5e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
HNRNPM
Tbio
Novelty: 0.01865149
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.42

PubMed score by year
PubTator Score  87.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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