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Tbio
GJA5
Gap junction alpha-5 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene may be associated with atrial fibrillation. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000579774
  • ENSP00000463851
  • ENSG00000265107
  • ENST00000621517
  • ENSP00000484552

Symbol
  • CX40
  • ATFB11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
protein domain
0.73
tissue sample
0.73
biological term
0.62
cell type or tissue
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.75   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 277   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 494.75   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 277   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1
46.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
46.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gap junction protein alpha 5
701163
Mouse
MGI:95716
14613
Rat
RGD:2692
50563
Dog
gap junction protein alpha 5
VGNC:41235
483155
Horse
gap junction protein alpha 5
VGNC:18352
100065052
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gap junction protein alpha 5
Mouse
Rat
Dog
gap junction protein alpha 5
Horse
gap junction protein alpha 5
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P36382-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (60)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Non-traceable Author Statement (NAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (102)
1 – 10 of 102
NKX2-5
Tbio
Family: TF
Novelty: 0.00125993
Score: 0.833
Data Source: STRINGDB
TBX5
Tbio
Family: TF
Novelty: 0.00272208
Score: 0.817
Data Source: STRINGDB
HCN4
Tclin
Family: IC
Novelty: 0.0021957
Score: 0.792
Data Source: STRINGDB
TBX3
Tbio
Family: TF
Novelty: 0.00515507
Score: 0.784
Data Source: STRINGDB
GJB1
Tbio
Novelty: 0.00109019
Score: 0.748
Data Source: STRINGDB
GJD3
Tbio
Novelty: 0.05441345
Score: 0.747
Data Source: STRINGDB
GJA1
Tbio
Novelty: 0.00021332
Score: 0.744
Data Source: STRINGDB
GJB2
Tbio
Novelty: 0.00056398
Score: 0.737
Data Source: STRINGDB
GJA8
Tbio
Novelty: 0.00377739
Score: 0.734
Data Source: STRINGDB
SCN5A
Tclin
Family: IC
Novelty: 0.00050944
Score: 0.722
Data Source: STRINGDB
Publication Statistics
PubMed Score  494.75

PubMed score by year
PubTator Score  202.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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