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Tbio
CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

Protein Summary
Description
Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation. This gene encodes a protein which interacts with the carboxy-terminus of the RAP74 subunit of transcription initiation factor TFIIF, and functions as a phosphatase that processively dephosphorylates the C-terminus of POLR2A (a subunit of RNA polymerase II), making it available for initiation of gene expression. Mutations in this gene are associated with congenital cataracts, facial dysmorphism and neuropathy syndrome (CCFDN). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000075430
  • ENSP00000075430
  • ENSG00000060069
  • ENST00000613122
  • ENSP00000484525

Symbol
  • FCP1
  • FCP1
  • CCFDN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.89
histone modification site profile
0.84
pathway
0.78
small molecule perturbation
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.62   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.62   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
86.6
monocyte percentage of leukocytes
1
1
1
43.7
smoking initiation
1
1
1
30.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
86.6
monocyte percentage of leukocytes
1
43.7
smoking initiation
1
30.6
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Abortive elongation of HIV-1 transcript in the absence of Tat (R-HSA-167242)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abortive elongation of HIV-1 transcript in the absence of Tat
Reactome
Disease
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Reactome
Formation of RNA Pol II elongation complex
Name
Explore in Pharos
Explore in Source
Abortive elongation of HIV-1 transcript in the absence of Tat
Disease
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Formation of RNA Pol II elongation complex
Protein-Protein Interactions (144)
1 – 10 of 144
RPRD1B
Tbio
Novelty: 0.0444394
p_int: 0.999999082
p_ni: 1e-7
p_wrong: 8.19e-7
Score: 0.855
Data Source: BioPlex,STRINGDB
FGF12
Tbio
Novelty: 0.02094849
p_int: 0.999986443
p_ni: 0.000001509
p_wrong: 0.000012048
Data Source: BioPlex
POLR2G
Tbio
Family: Enzyme
Novelty: 0.01235379
p_int: 0.999910207
p_ni: 0.000003448
p_wrong: 0.000086344
Score: 0.996
Data Source: BioPlex,STRINGDB
GTF2F1
Tbio
Novelty: 0.02118098
Score: 0.997
Data Source: Reactome,STRINGDB
POLR2A
Tbio
Family: Enzyme
Novelty: 0.00188323
Score: 0.994
Data Source: STRINGDB
GTF2F2
Tbio
Novelty: 0.02446629
Score: 0.993
Data Source: Reactome,STRINGDB
POLR2B
Tbio
Family: Enzyme
Novelty: 0.0012624
Score: 0.986
Data Source: STRINGDB
GTF2B
Tbio
Novelty: 0.00179492
Score: 0.985
Data Source: STRINGDB
SUPT5H
Tbio
Novelty: 0.00775042
Score: 0.984
Data Source: Reactome,STRINGDB
POLR2C
Tbio
Family: Enzyme
Novelty: 0.01652813
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  89.62

PubMed score by year
PubTator Score  11.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer