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Tdark
TMEM114
Transmembrane protein 114

Protein Summary
Description
This gene encodes a glycosylated transmembrane protein that plays a role in lens and eye development. Mutations in this gene, including a t(16;22)(p13.3;q11.2) translocation, are associated with congenital and juvenile cataract disorders. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000620492
  • ENSP00000484263
  • ENSG00000232258
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.65
transcription factor binding site profile
0.46
chemical
0.41
cellular component
0.38
gene perturbation
0.37


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.57   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (43)
1 – 10 of 43
RCHY1
Tbio
Novelty: 0.01853663
Score: 0.8
Data Source: STRINGDB
CHMP4B
Tbio
Novelty: 0.01391352
Score: 0.777
Data Source: STRINGDB
LIM2
Tbio
Novelty: 0.01252353
Score: 0.763
Data Source: STRINGDB
CRYBB2
Tbio
Novelty: 0.00721869
Score: 0.744
Data Source: STRINGDB
CRYBB1
Tbio
Novelty: 0.01083645
Score: 0.74
Data Source: STRINGDB
GJA3
Tbio
Novelty: 0.00638283
Score: 0.737
Data Source: STRINGDB
BFSP1
Tbio
Novelty: 0.01519136
Score: 0.734
Data Source: STRINGDB
CRYBB3
Tbio
Novelty: 0.0455879
Score: 0.708
Data Source: STRINGDB
CRYBA4
Tbio
Novelty: 0.03692663
Score: 0.703
Data Source: STRINGDB
CRYGD
Tbio
Novelty: 0.00246109
Score: 0.699
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.57

PubMed score by year
PubTator Score  4.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer