CABYR
Calcium-binding tyrosine phosphorylation-regulated protein
Protein Summary
May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction. Isoform 1 binds calcium in vitro. Isoform 2 and isoform 6 probably bind calcium. Isoform 3 and isoform 5 do not bind calcium in vitro. Isoform 4 probably does not bind calcium. To reach fertilization competence, spermatozoa undergo a series of morphological and molecular maturational processes, termed capacitation, involving protein tyrosine phosphorylation and increased intracellular calcium. The protein encoded by this gene localizes to the principal piece of the sperm flagellum in association with the fibrous sheath and exhibits calcium-binding when phosphorylated during capacitation. A pseudogene on chromosome 3 has been identified for this gene. Alternatively spliced transcript variants encoding distinct protein isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
- ENST00000327201
- ENSP00000317095
- ENSG00000154040
- ENST00000399481
- ENSP00000382404
- ENST00000399496
- ENSP00000382419
- ENST00000399499
- ENSP00000382421
- ENST00000415309
- ENSP00000399973
- ENST00000463087
- ENSP00000432870
- ENST00000486759
- ENSP00000431142
- ENST00000621648
- ENSP00000483621
- CBP86
- FSP2
- CT88
- FSP2
- CBP86
- FSP-2
- CABYRa
- CABYRc
- CABYRe
- CABYRc/d
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.84 | ||
cell type or tissue | 0.71 | ||
tissue sample | 0.66 | ||
transcription factor | 0.66 | ||
cellular component | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.21 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 80 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 26.21 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 80 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (37)
Nearest Tclin Targets
Pathways (0)
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (8)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Non-traceable Author Statement (NAS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 1 | 2 | 2 | 82 | |||||
monocyte percentage of leukocytes | 1 | 1 | 1 | 61 | |||||
leukocyte count | 1 | 1 | 1 | 46.9 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 82 | |||||
monocyte percentage of leukocytes | 1 | 61 | |||||
leukocyte count | 1 | 46.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | calcium binding tyrosine phosphorylation regulated | VGNC:8869 | 455342 | |||||
Macaque | calcium binding tyrosine phosphorylation regulated | 701670 | ||||||
Mouse | MGI:1918382 | 71132 | ||||||
Rat | RGD:1585413 | 686189 | ||||||
Dog | calcium binding tyrosine phosphorylation regulated | VGNC:38629 | 100270706 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | calcium binding tyrosine phosphorylation regulated | |||||
Macaque | calcium binding tyrosine phosphorylation regulated | |||||
Mouse | ||||||
Rat | ||||||
Dog | calcium binding tyrosine phosphorylation regulated | |||||
Publication Statistics
PubMed Score 26.21
PubMed score by year
PubTator Score 16.82
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (12)
Items per page:
0 of 0
PMID | Year | Title |
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