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Tbio
DDX27
Probable ATP-dependent RNA helicase DDX27

Protein Summary
Description
Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3' end formation of ribosomal 47S rRNA (PubMed:25825154). DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371764
  • ENSP00000360828
  • ENSG00000124228
  • ENST00000622530
  • ENSP00000483495

Symbol
  • cPERP-F
  • RHLP
  • DRS1
  • RHLP
  • Drs1p
  • PP3241
  • HSPC259
  • dJ686N3.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
disease perturbation
0.95
molecular function
0.94
drug perturbation
0.87
interacting protein
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
2
1
1
6.9
87.5
body height
1
1
1
18.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.9
87.5
body height
1
18.4
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (328)
1 – 10 of 328
PES1
Tbio
Novelty: 0.07162845
p_int: 0.988154901
p_ni: 0.011845099
Score: 0.973
Data Source: BioPlex,STRINGDB
RPL37A
Tbio
Novelty: 0.03475061
p_int: 0.980247599
p_ni: 0.019752401
Score: 0.532
Data Source: BioPlex,STRINGDB
RPL7L1
Tdark
Novelty: 0.78428937
p_int: 0.972156216
p_ni: 0.027843784
Score: 0.473
Data Source: BioPlex,STRINGDB
RBM34
Tdark
Novelty: 0.58131282
p_int: 0.967426362
p_ni: 0.032573637
Score: 0.981
Data Source: BioPlex,STRINGDB
RPL11
Tbio
Novelty: 0.00448962
p_int: 0.963383588
p_ni: 0.036616412
Score: 0.189
Data Source: BioPlex,STRINGDB
RPL30
Tbio
Novelty: 0.0134194
p_int: 0.959093323
p_ni: 0.040906677
Score: 0.616
Data Source: BioPlex,STRINGDB
MAK16
Tdark
Novelty: 0.07717917
p_int: 0.94580459
p_ni: 0.05419541
Score: 0.963
Data Source: BioPlex,STRINGDB
DGCR8
Tbio
Novelty: 0.00271221
p_int: 0.934697175
p_ni: 0.065302825
Data Source: BioPlex
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.931402231
p_ni: 0.068597769
Score: 0.385
Data Source: BioPlex,STRINGDB
WDR46
Tbio
Novelty: 0.19307408
p_int: 0.922730239
p_ni: 0.077269761
Score: 0.916
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  7.61

PubMed score by year
PubTator Score  4.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer