You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IFI27
Interferon alpha-inducible protein 27, mitochondrial

Protein Summary
Description
Probable adapter protein involved in different biological processes (PubMed:22427340, PubMed:27194766). Part of the signaling pathways that lead to apoptosis (PubMed:18330707, PubMed:27673746, PubMed:24970806). Involved in type-I interferon-induced apoptosis characterized by a rapid and robust release of cytochrome C from the mitochondria and activation of BAX and caspases 2, 3, 6, 8 and 9 (PubMed:18330707, PubMed:27673746). Also functions in TNFSF10-induced apoptosis (PubMed:24970806). May also have a function in the nucleus, where it may be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). May thereby play a role in the vascular response to injury (By similarity). In the innate immune response, has an antiviral activity towards hepatitis C virus/HCV (PubMed:27194766, PubMed:27777077). May prevent the replication of the vi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000612813
  • ENSP00000483430
  • ENSG00000165949
  • ENST00000612838
  • ENSP00000483932
  • ENSG00000275214
  • ENST00000613997
  • ENSP00000484089
  • ENST00000615978
  • ENSP00000483291
  • ENST00000616764
  • ENSP00000477753
  • ENST00000618863
  • ENSP00000482635
  • ENST00000621160
  • ENSP00000483498
  • ENST00000627111
  • ENSP00000486608

Symbol
  • P27
  • ISG12
  • FAM14D
  • ISG12A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
small molecule perturbation
0.94
gene perturbation
0.83
cellular component
0.7
biological process
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.88   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.88   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Protein-Protein Interactions (150)
1 – 10 of 150
ISG15
Tbio
Novelty: 0.00256125
Score: 0.992
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00081841
Score: 0.988
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.00786985
Score: 0.982
Data Source: STRINGDB
OAS1
Tbio
Family: Enzyme
Novelty: 0.00774033
Score: 0.978
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00862855
Score: 0.975
Data Source: STRINGDB
IFI6
Tbio
Novelty: 0.04401105
Score: 0.975
Data Source: STRINGDB
IFITM1
Tbio
Novelty: 0.00636614
Score: 0.969
Data Source: STRINGDB
IFIT3
Tbio
Novelty: 0.00899003
Score: 0.969
Data Source: STRINGDB
OASL
Tbio
Family: Enzyme
Novelty: 0.02020019
Score: 0.965
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.88

PubMed score by year
PubTator Score  1699.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: