Protein Classes
Protein Summary
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain f ...more
- ENST00000230882
- ENSP00000230882
- ENSG00000112964
- ENST00000357703
- ENSP00000350335
- ENST00000537449
- ENSP00000442206
- ENST00000612382
- ENSP00000478332
- ENST00000612626
- ENSP00000479846
- ENST00000615111
- ENSP00000478291
- ENST00000618088
- ENSP00000482373
- GHBP
- GHIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
biological process | 0.95 | ||
PubMedID | 0.92 | ||
hub protein | 0.88 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 901.83 (req: < 5)
Gene RIFs: 197 (req: <= 3)
Antibodies: 362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 901.83 (req: >= 5)
Gene RIFs: 197 (req: > 3)
Antibodies: 362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
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PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (35)
Reactome (4)
KEGG (4)
PathwayCommons (5)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Growth hormone receptor signaling | ||||
Reactome | Immune System | ||||
Reactome | Prolactin receptor signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Growth hormone receptor signaling | ||||
Immune System | ||||
Prolactin receptor signaling | ||||
Gene Ontology Terms (48)
Functions (9)
Components (11)
Processes (28)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Protein-Protein Interactions (137)
1 – 10 of 137
GH1
Novelty: 0.00082468
Score: 0.996
Data Source: Reactome,STRINGDB
JAK2
Family: Kinase
Novelty: 0.00028252
Score: 0.989
Data Source: Reactome,STRINGDB
STAT5B
Family: TF
Novelty: 0.00091216
Score: 0.983
Data Source: Reactome,STRINGDB
STAT5A
Family: TF
Novelty: 0.00091229
Score: 0.982
Data Source: Reactome,STRINGDB
GH2
Novelty: 0.00081585
Score: 0.975
Data Source: Reactome,STRINGDB
SOCS3
Novelty: 0.00082008
Score: 0.973
Data Source: Reactome,STRINGDB
SOCS2
Novelty: 0.00459272
Score: 0.97
Data Source: Reactome,STRINGDB
CISH
Novelty: 0.00075253
Score: 0.969
Data Source: Reactome,STRINGDB
PRL
Novelty: 0.00010121
Score: 0.962
Data Source: STRINGDB
IRS1
Novelty: 0.00061858
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score 901.83
PubMed score by year
PubTator Score 1049.49
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTD
1-70
EVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKC
70-140
FSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPI
140-210
LTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTV
210-280
MLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDI
280-350
DEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGE
350-420
ADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQV
420-490
SDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSL
490-560
NQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVST
560-630
DQLNKIMP
630-638
MDLWQLLLTLALAGSSDAFSGSEATAAILSRAPWSLQSVNPGLKTNSSKEPKFTKCRSPERETFSCHWTDEVHHGTKNLGPIQLFYTRRNTQEWTQEWKECPDYVSAGENSCYFNSSFTSIWIPYCIKLTSNGGTVDEKCFSVDEIVQPDPPIALNWTLLNVSLTGIHADIQVRWEAPRNADIQKGWMVLEYELQYKEVNETKWKMMDPILTTSVPVYSLKVDKEYEVRVRSKQRNSGNYGEFSEVLYVTLPQMSQFTCEEDFYFPWLLIIIFGIFGLTVMLFVFLFSKQQRIKMLILPPVPVPKIKGIDPDLLKEGKLEEVNTILAIHDSYKPEFHSDDSWVEFIELDIDEPDEKTEESDTDRLLSSDHEKSHSNLGVKDGDSGRTSCCEPDILETDFNANDIHEGTSEVAQPQRLKGEADLLCLDQKNQNNSPYHDACPATQQPSVIQAEKNKPQPLPTEGAESTHQAAHIQLSNPSSLSNIDFYAQVSDITPAGSVVLSPGQKNKAGMSQCDMHPEMVSLCQENFLMDNAYFCEADAKKCIPVAPHIKVESHIQPSLNQEDIYITTESLTTAAGRPGTGEHVPGSEMPVPDYTSIHIVQSPQGLILNATALPLPDKEFLSSCGYVSTDQLNKIMP
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