Pharos: Illuminating the Druggable Genome

Tclin

Protein Classes

Protein Summary

Description

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain f ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000230882
ENSP00000230882
ENSG00000112964
ENST00000357703
ENSP00000350335
ENST00000537449
ENSP00000442206
ENST00000612382
ENSP00000478332
ENST00000612626
ENSP00000479846
ENST00000615111
ENSP00000478291
ENST00000618088
ENSP00000482373

Symbol

GHBP
GHIP

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1

disease perturbation	0.96

biological process	0.95

PubMedID	0.92

hub protein	0.88

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.83 (req: < 5)

View Publications

Gene RIFs: 197 (req: <= 3)

View Gene RIFs

Antibodies: 362 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 901.83 (req: >= 5)

Gene RIFs: 197 (req: > 3)

Antibodies: 362 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3

Explore Approved Drugs

Approved Drugs (3)

1 – 3 of 3

pegvisomant

somatrem

somatropin

Protein Data Bank (9)

1 – 5 of 9

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (35)

Reactome (4)

KEGG (4)

PathwayCommons (5)

WikiPathways (22)

Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Reactome	Growth hormone receptor signaling	24 targets	R-HSA-982772

Reactome	Immune System	2246 targets	R-HSA-168256

Reactome	Prolactin receptor signaling	15 targets	R-HSA-1170546

Name	Explore in Pharos	Explore in Source
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215

Growth hormone receptor signaling	24 targets	R-HSA-982772

Immune System	2246 targets	R-HSA-168256

Prolactin receptor signaling	15 targets	R-HSA-1170546

Gene Ontology Terms (48)

Functions (9)

Components (11)

Processes (28)

Items per page:

1 – 9 of 9

GO Term	Evidence	Assigned by
protein homodimerization activity	Inferred from Direct Assay (IDA)	BHF-UCL

growth factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL

identical protein binding	Inferred from Physical Interaction (IPI)	IntAct

peptide hormone binding	Inferred from Physical Interaction (IPI)	BHF-UCL

cytokine binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

cytokine receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

growth hormone receptor activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

proline-rich region binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

protein kinase binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL

Protein-Protein Interactions (137)

1 – 10 of 137

See Interactions on String-DB

GH1

Tbio

Novelty: 0.00082468

Score: 0.996