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Tchem
ACACA
Acetyl-CoA carboxylase 1

Protein Summary
Description
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000611803
  • ENSP00000479901
  • ENSG00000275176
  • ENST00000612895
  • ENSP00000482269
  • ENSG00000278540
  • ENST00000613687
  • ENSP00000483674
  • ENST00000614428
  • ENSP00000478547
  • ENST00000616317
  • ENSP00000483300
  • ENST00000617649
  • ENSP00000482368
  • ENST00000619487
  • ENSP00000478577
  • ENST00000621312
  • ENSP00000480031

Symbol
  • ACAC
  • ACC1
  • ACCA
  • ACC
  • ACAC
  • ACC1
  • ACCA
  • ACACAD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
protein domain
1
biological process
0.97
molecular function
0.94
transcription factor
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.31   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 581   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 374.31   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 581   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 255
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
1
1
31.3
macrophage inflammatory protein 1b measurement
1
1
1
31.3
Items per page:
1 – 2 of 2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
31.3
macrophage inflammatory protein 1b measurement
1
31.3
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (78)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Biotin transport and metabolism
Reactome
ChREBP activates metabolic gene expression
Reactome
Defective HLCS causes multiple carboxylase deficiency
Reactome
Defects in biotin (Btn) metabolism
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Biotin transport and metabolism
ChREBP activates metabolic gene expression
Defective HLCS causes multiple carboxylase deficiency
Defects in biotin (Btn) metabolism
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (201)
1 – 10 of 201
MID1IP1
Tbio
Novelty: 0.11443752
p_int: 0.999904045
p_ni: 0.000095955
Score: 0.492
Data Source: BioPlex,STRINGDB
OAS2
Tbio
Family: Enzyme
Novelty: 0.01673393
p_int: 0.999807845
p_ni: 0.000192155
Score: 0.269
Data Source: BioPlex,STRINGDB
THRSP
Tbio
Novelty: 0.00938864
p_int: 0.999231516
p_ni: 0.000768484
Score: 0.656
Data Source: BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty: 0.0025302
p_int: 0.992027139
p_ni: 0.007972861
Data Source: BioPlex
ODAPH
Tbio
Novelty: 0.20386223
p_int: 0.989582378
p_ni: 0.010417622
Data Source: BioPlex
EGLN3
Tclin
Novelty: 0.00643992
p_int: 0.984992108
p_ni: 0.015007892
Data Source: BioPlex
PSG1
Tbio
Novelty: 0.0239046
p_int: 0.974052539
p_ni: 0.025947461
Score: 0.181
Data Source: BioPlex,STRINGDB
SGCZ
Tbio
Novelty: 0.08511312
p_int: 0.928173054
p_ni: 0.071826946
Score: 0.187
Data Source: BioPlex,STRINGDB
TNS4
Tbio
Novelty: 0.048713
p_int: 0.861707664
p_ni: 0.138292336
Data Source: BioPlex
FNDC11
Tdark
Novelty: 20.00979352
p_int: 0.817664629
p_ni: 0.182335371
Score: 0.309
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  374.31

PubMed score by year
PubTator Score  142.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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