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Tbio
RIPOR2
Rho family-interacting cell polarization regulator 2

Protein Summary
Description
Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization (PubMed:17150207, PubMed:24687993, PubMed:23241886, PubMed:24958875, PubMed:25588844, PubMed:27556504). Inhibits chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration (PubMed:23241886). Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion (By similarity). Required for normal development of inner and outer hair cell stereocilia within the cochlea of the inner ear (By similarity). Plays a role for maintaining the structural organization of the basal domain of stereocilia (By similarity). Involved in mechanosensory hair cell function (By similarity). Required for normal hearing (PubMed:24958875). Isoform 2: Acts as an inhibitor of the small GTPase RHOA (PubMed:25588844). Plays a role in fetal mononuclear myoblast differentiation by promot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259698
  • ENSP00000259698
  • ENSG00000111913
  • ENST00000378023
  • ENSP00000367262
  • ENST00000613507
  • ENSP00000482957
  • ENST00000643623
  • ENSP00000495245
  • ENST00000644621
  • ENSP00000495914
  • ENST00000644685
  • ENSP00000496721

Symbol
  • C6orf32
  • DIFF48
  • FAM65B
  • KIAA0386
  • PL48
  • PL48
  • DIFF40
  • DIFF48
  • FAM65B
  • MYONAP
  • C6orf32
  • DFNB104
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.23   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 149   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.23   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 149   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
1
2
62.2
lymphocyte count
2
1
2
58.6
neutrophil percentage of leukocytes
2
1
2
58.2
monocyte count
1
1
1
51.3
electrocardiography
1
1
5
34.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
2
62.2
lymphocyte count
2
58.6
neutrophil percentage of leukocytes
2
58.2
monocyte count
1
51.3
electrocardiography
5
34.3
Gene Ontology Terms (32)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (40)
1 – 10 of 40
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.786
Data Source: STRINGDB
CANT1
Tbio
Family: Enzyme
Novelty: 0.02640333
Score: 0.682
Data Source: STRINGDB
IGFN1
Tbio
Novelty: 0.23407022
Score: 0.665
Data Source: STRINGDB
MSS51
Tbio
Novelty: 0.06388791
Score: 0.654
Data Source: STRINGDB
MYBPH
Tbio
Novelty: 0.00247863
Score: 0.644
Data Source: STRINGDB
MYOG
Tbio
Family: TF
Novelty: 0.00074867
Score: 0.623
Data Source: STRINGDB
C6orf62
Tdark
Novelty: 1.21509188
Score: 0.586
Data Source: STRINGDB
ACTC1
Tbio
Novelty: 0.00188036
Score: 0.573
Data Source: STRINGDB
ST8SIA3
Tbio
Family: Enzyme
Novelty: 0.05984127
Score: 0.562
Data Source: STRINGDB
KIAA0319
Tbio
Novelty: 0.01425914
Score: 0.543
Data Source: STRINGDB
Publication Statistics
PubMed Score  15.23

PubMed score by year
PubTator Score  11.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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