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Tbio
BCL2L12
Bcl-2-like protein 12

Protein Summary
Description
This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246785
  • ENSP00000246785
  • ENSG00000126453
  • ENST00000441864
  • ENSP00000393803
  • ENST00000616144
  • ENSP00000482218

Symbol
  • BPR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
biological process
0.74
tissue sample
0.71
ligand (protein) perturbation
0.59
transcription factor binding site profile
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.24   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.24   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
AMY2A
Tclin
Family:  Enzyme
Novelty:  0.00132709
p_int:  0.996068151
p_ni:  0.002730038
p_wrong:  0.00120181
Score:  0.68
Data Source:  BioPlex,STRINGDB
BAX
Tchem
Novelty:  0.00150653
p_int:  0.995879491
p_ni:  0.004120509
Score:  0.579
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.992518124
p_ni:  0.007473174
p_wrong:  0.000008702
Data Source:  BioPlex
PPP1R9A
Tbio
Novelty:  0.04851082
p_int:  0.972842043
p_ni:  0.008561537
p_wrong:  0.01859642
Score:  0.228
Data Source:  BioPlex,STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.756
Data Source:  STRINGDB
BCL2L1
Tchem
Novelty:  0.00018414
Score:  0.746
Data Source:  STRINGDB
SCAF1
Tbio
Novelty:  0.08705338
Score:  0.707
Data Source:  STRINGDB
PRR12
Tdark
Novelty:  0.19188825
Score:  0.706
Data Source:  STRINGDB
PRRG2
Tbio
Novelty:  0.16164794
Score:  0.689
Data Source:  STRINGDB
NAIF1
Tbio
Novelty:  0.1179429
Score:  0.628
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Regulation of Apoptosis by Parathyroid Hormone-related Protein
WikiPathways
Regulation of Apoptosis by Parathyroid Hormone-related Protein
WikiPathways
Integrin-mediated Cell Adhesion
WikiPathways
Ebola Virus Pathway on Host
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Name
Explore in Pharos
Explore in Source
Regulation of Apoptosis by Parathyroid Hormone-related Protein
Regulation of Apoptosis by Parathyroid Hormone-related Protein
Integrin-mediated Cell Adhesion
Ebola Virus Pathway on Host
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
6
6
97
serum albumin measurement
1
4
4
92.1
hemoglobin measurement
2
2
2
90.5
red blood cell density measurement
1
1
1
80.9
urate measurement
2
2
4
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
6
97
serum albumin measurement
4
92.1
hemoglobin measurement
2
90.5
red blood cell density measurement
1
80.9
urate measurement
4
71.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 12
VGNC:6615
456213
Macaque
BCL2 like 12
718981
Mouse
MGI:1922986
75736
Rat
RGD:1307361
361567
Dog
BCL2 like 12
VGNC:53525
100688537
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 like 12
Macaque
BCL2 like 12
Mouse
Rat
Dog
BCL2 like 12
Publication Statistics
PubMed Score 73.24
PubMed score by year
PubTator Score 43.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title