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Tbio
NEFL
Neurofilament light polypeptide

Protein Summary
Description
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000610854
  • ENSP00000482169
  • ENSG00000277586

Symbol
  • NF68
  • NFL
  • NFL
  • NF-L
  • NF68
  • CMT1F
  • CMT2E
  • CMTDIG
  • PPP1R110
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
hub protein
0.97
PubMedID
0.91
biological process
0.9
kinase
0.78


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2146.75   (req: < 5)
Gene RIFs: 84   (req: <= 3)
Antibodies: 947   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2146.75   (req: >= 5)
Gene RIFs: 84   (req: > 3)
Antibodies: 947   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neurofilament light
641444
Mouse
MGI:97313
18039
Rat
RGD:621458
83613
Cow
neurofilament light
VGNC:31986
281348
Pig
neurofilament light
100521224
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neurofilament light
Mouse
Rat
Cow
neurofilament light
Pig
neurofilament light
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P07196-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (25)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Assembly and cell surface presentation of NMDA receptors
Reactome
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Assembly and cell surface presentation of NMDA receptors
CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling
Cytokine Signaling in Immune system
FLT3 Signaling
Gene Ontology Terms (46)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (159)
1 – 10 of 159
NEFM
Tbio
Novelty: 0.00239134
p_int: 0.999997053
p_ni: 0.000002947
Score: 0.968
Data Source: BioPlex,STRINGDB
VIM
Tbio
Novelty: 0.00030317
p_int: 0.999969372
p_ni: 0.000030628
Score: 0.694
Data Source: BioPlex,STRINGDB
BICD2
Tbio
Novelty: 0.01725046
p_int: 0.999885206
p_ni: 0.000114794
Score: 0.324
Data Source: BioPlex,STRINGDB
NEFH
Tbio
Novelty: 0.0013027
p_int: 0.999791441
p_ni: 0.000208557
p_wrong: 2e-9
Score: 0.71
Data Source: BioPlex,STRINGDB
SYNC
Tbio
Novelty: 0.04605223
p_int: 0.99967885
p_ni: 0.00032115
Score: 0.708
Data Source: BioPlex,STRINGDB
BICD1
Tbio
Novelty: 0.02109123
p_int: 0.998638849
p_ni: 0.000321349
p_wrong: 0.001039802
Score: 0.199
Data Source: BioPlex,STRINGDB
RSPRY1
Tdark
Novelty: 0.26883105
p_int: 0.996353123
p_ni: 0.003646877
Score: 0.313
Data Source: BioPlex,STRINGDB
DPP9
Tchem
Family: Enzyme
Novelty: 0.00976924
p_int: 0.993578888
p_ni: 0.006421112
Data Source: BioPlex
RMC1
Tbio
Novelty: 0.02804116
p_int: 0.987325968
p_ni: 0.000282655
p_wrong: 0.012391377
Score: 0.237
Data Source: BioPlex,STRINGDB
MAP7
Tbio
Novelty: 0.01976296
p_int: 0.976732212
p_ni: 0.023267788
Data Source: BioPlex
Publication Statistics
PubMed Score  2146.75

PubMed score by year
PubTator Score  600.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer