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Tbio
CREB3L1
Cyclic AMP-responsive element-binding protein 3-like protein 1

Protein Summary
Description
Transcription factor involved in unfolded protein response (UPR). Binds the DNA consensus sequence 5'-GTGXGCXGC-3' (PubMed:21767813). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation through the transcription of COL1A1, and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not regulate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-indu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000621158
  • ENSP00000481956
  • ENSG00000157613

Symbol
  • OASIS
  • OI16
  • OASIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.77
transcription factor perturbation
0.74
cell type or tissue
0.7
molecular function
0.7
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.39   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 260   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.39   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 260   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
1
2
62
venous thromboembolism
1
1
1
55.3
alcohol use disorder measurement
1
1
1
49
1
1
1
48.2
unipolar depression
1
1
1
48.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alcohol consumption measurement
2
62
venous thromboembolism
1
55.3
alcohol use disorder measurement
1
49
1
48.2
unipolar depression
1
48.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1347062
26427
Rat
RGD:1359613
362165
Dog
cAMP responsive element binding protein 3 like 1
VGNC:39597
483636
Horse
cAMP responsive element binding protein 3 like 1
VGNC:16854
100057002
Cow
cAMP responsive element binding protein 3 like 1
VGNC:27694
513105
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
cAMP responsive element binding protein 3 like 1
Horse
cAMP responsive element binding protein 3 like 1
Cow
cAMP responsive element binding protein 3 like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96BA8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (43)
CREB3 factors activate genes (R-HSA-8874211)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
CREB3 factors activate genes
Reactome
Metabolism of proteins
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
CREB3 factors activate genes
Metabolism of proteins
Unfolded Protein Response (UPR)
Gene Ontology Terms (24)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Protein-Protein Interactions (90)
1 – 10 of 90
FBXW7
Tbio
Novelty: 0.00180856
p_int: 0.999989394
p_ni: 0.000010518
p_wrong: 8.8e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
CREB3L2
Tbio
Family: TF
Novelty: 0.0284456
p_int: 0.999962414
p_ni: 5.6e-8
p_wrong: 0.000037529
Score: 0.885
Data Source: BioPlex,STRINGDB
UHRF1BP1
Tbio
Novelty: 0.1588079
p_int: 0.999703414
p_ni: 0.000296585
p_wrong: 1e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
TRRAP
Tbio
Novelty: 0.01517245
p_int: 0.920121232
p_ni: 0.079878767
Score: 0.175
Data Source: BioPlex,STRINGDB
AP3B1
Tbio
Novelty: 0.03117931
p_int: 0.879678345
p_ni: 0.120321652
p_wrong: 4e-9
Score: 0.287
Data Source: BioPlex,STRINGDB
USP22
Tbio
Family: Enzyme
Novelty: 0.01416662
p_int: 0.827968203
p_ni: 0.167148974
p_wrong: 0.004882823
Score: 0.163
Data Source: BioPlex,STRINGDB
MBTPS1
Tchem
Family: Enzyme
Novelty: 0.00845881
Score: 0.959
Data Source: Reactome,STRINGDB
MBTPS2
Tbio
Family: Enzyme
Novelty: 0.00625665
Score: 0.958
Data Source: Reactome,STRINGDB
CREB3L3
Tbio
Family: TF
Novelty: 0.02519904
Score: 0.928
Data Source: STRINGDB
CREB3
Tbio
Family: TF
Novelty: 0.00424318
Score: 0.925
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.39

PubMed score by year
PubTator Score  511.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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