You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SERPINI2
Serpin I2

Protein Summary
Description
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264677
  • ENSP00000264677
  • ENSG00000114204
  • ENST00000461846
  • ENSP00000417692
  • ENST00000471111
  • ENSP00000419407
  • ENST00000476257
  • ENSP00000420621

Symbol
  • MEPI
  • PI14
  • MEPI
  • PI14
  • PANCPIN
  • TSA2004
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.59
cell type or tissue
0.53
gene perturbation
0.51
tissue
0.42
protein domain
0.41


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.32   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.32   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
2
1
2
22.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diet measurement
2
22.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family I member 2
VGNC:10045
460831
Macaque
serpin family I member 2
699036
Mouse
MGI:1915181
67931
Rat
RGD:619897
171149
Dog
serpin family I member 2
VGNC:46043
609110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family I member 2
Macaque
serpin family I member 2
Mouse
Rat
Dog
serpin family I member 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O75830-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (4)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (19)
1 – 10 of 19
PI15
Tbio
Family: Enzyme
Novelty: 0.02244161
Score: 0.7
Data Source: STRINGDB
PSMF1
Tbio
Novelty: 0.0364376
Score: 0.686
Data Source: STRINGDB
RPE65
Tbio
Family: Enzyme
Novelty: 0.00147985
Score: 0.615
Data Source: STRINGDB
PI16
Tbio
Family: Enzyme
Novelty: 0.01826735
Score: 0.608
Data Source: STRINGDB
CPB1
Tchem
Family: Enzyme
Novelty: 0.00108031
Score: 0.587
Data Source: STRINGDB
PLAT
Tclin
Family: Enzyme
Novelty: 0.00017503
Score: 0.545
Data Source: STRINGDB
PLAU
Tchem
Family: Enzyme
Novelty: 0.0005322
Score: 0.545
Data Source: STRINGDB
ZBBX
Tdark
Novelty: 1.66474399
Score: 0.508
Data Source: STRINGDB
PLG
Tclin
Family: Enzyme
Novelty: 0.00004806
Score: 0.48
Data Source: STRINGDB
SGTB
Tbio
Novelty: 0.03243414
Score: 0.48
Data Source: STRINGDB
Publication Statistics
PubMed Score  44.32

PubMed score by year
PubTator Score  37.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: