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Tbio
FAM83D
Protein FAM83D

Protein Summary
Description
Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition. Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000619850
  • ENSP00000481465
  • ENSG00000101447

Symbol
  • C20orf129
  • CHICA
  • C20orf129
  • dJ616B8.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.77
transcription factor perturbation
0.74
virus perturbation
0.72
tissue sample
0.68
kinase perturbation
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 75   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.26   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 75   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (120)
1 – 10 of 120
BACH1
Tbio
Family: TF
Novelty: 0.04011328
p_int: 0.999998602
p_ni: 0.000001398
Score: 0.203
Data Source: BioPlex,STRINGDB
HMMR
Tbio
Novelty: 0.0039196
p_int: 0.999995397
p_ni: 0.000004603
Score: 0.971
Data Source: BioPlex,STRINGDB
CRYAA
Tbio
Novelty: 0.01914081
p_int: 0.999584273
p_ni: 0.000415727
Data Source: BioPlex
ZAR1L
Tdark
Novelty: 0.08793345
p_int: 0.999576482
p_ni: 0.000423518
Data Source: BioPlex
CSNK1A1
Tchem
Family: Kinase
Novelty: 0.00636472
p_int: 0.998946167
p_ni: 0.001053833
Score: 0.566
Data Source: BioPlex,STRINGDB
CCDC40
Tbio
Novelty: 0.06726469
p_int: 0.99880831
p_ni: 0.00119169
Score: 0.625
Data Source: BioPlex,STRINGDB
GMNN
Tbio
Novelty: 0.00436572
p_int: 0.997443058
p_ni: 0.002556942
Score: 0.356
Data Source: BioPlex,STRINGDB
PSMC3
Tbio
Family: Enzyme
Novelty: 0.04026019
p_int: 0.993376245
p_ni: 0.006623754
Data Source: BioPlex
TRAK2
Tbio
Novelty: 0.04192075
p_int: 0.984132662
p_ni: 0.01585552
p_wrong: 0.000011818
Data Source: BioPlex
BBS7
Tbio
Novelty: 0.03611111
p_int: 0.973404322
p_ni: 0.026594436
p_wrong: 0.000001242
Data Source: BioPlex
Publication Statistics
PubMed Score  22.26

PubMed score by year
PubTator Score  36.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer