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Tbio
DNAI1
Dynein intermediate chain 1, axonemal

Protein Summary
Description
Part of the dynein complex of respiratory cilia. This gene encodes a member of the dynein intermediate chain family. The encoded protein is part of the dynein complex in respiratory cilia. The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia and Kartagener syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242317
  • ENSP00000242317
  • ENSG00000122735

Symbol
  • PCD
  • DIC1
  • ICS1
  • CILD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
transcription factor
0.63
cellular component
0.59
transcription factor binding site profile
0.55
histone modification site profile
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.26   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.26   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal intermediate chain 1
VGNC:8816
465060
Macaque
dynein axonemal intermediate chain 1
701307
Mouse
MGI:1916172
68922
Rat
RGD:1565671
500442
Dog
dynein axonemal intermediate chain 1
VGNC:40020
474749
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynein axonemal intermediate chain 1
Macaque
dynein axonemal intermediate chain 1
Mouse
Rat
Dog
dynein axonemal intermediate chain 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UI46-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (13)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (106)
1 – 10 of 106
DNAH5
Tbio
Novelty: 0.01579144
Score: 0.965
Data Source: STRINGDB
DNAH11
Tbio
Novelty: 0.02448234
Score: 0.953
Data Source: STRINGDB
CCDC114
Tbio
Novelty: 0.12534741
Score: 0.934
Data Source: STRINGDB
DNALI1
Tbio
Novelty: 0.13865981
Score: 0.909
Data Source: STRINGDB
DNAH9
Tdark
Novelty: 0.04634487
Score: 0.908
Data Source: STRINGDB
NME8
Tbio
Novelty: 0.05439119
Score: 0.896
Data Source: STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.893
Data Source: STRINGDB
DYNLT3
Tbio
Novelty: 0.10969629
Score: 0.889
Data Source: STRINGDB
WDR63
Tdark
Novelty: 0.04141617
Score: 0.882
Data Source: STRINGDB
DNAH7
Tbio
Novelty: 0.13519686
Score: 0.88
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.26

PubMed score by year
PubTator Score  45.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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