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Tbio
NCAM1
Neural cell adhesion molecule 1

Protein Summary
Description
This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. (Microbial infection) Acts as a receptor for rabies virus. This gene encodes a cell adhesion protein which is a member of the immunoglobulin superfamily. The encoded protein is involved in cell-to-cell interactions as well as cell-matrix interactions during development and differentiation. The encoded protein has been shown to be involved in development of the nervous system, and for cells involved in the expansion of T cells and dendritic cells which play an important role in immune surveillance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316851
  • ENSP00000318472
  • ENSG00000149294
  • ENST00000529356
  • ENSP00000482205
  • ENST00000531044
  • ENSP00000484943
  • ENST00000621128
  • ENSP00000481083
  • ENST00000621850
  • ENSP00000480774

Symbol
  • NCAM
  • CD56
  • NCAM
  • MSK39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
transcription factor perturbation
0.91
trait
0.86
protein domain
0.85
cellular component
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4690.01   (req: < 5)
Gene RIFs: 263   (req: <= 3)
Antibodies: 3031   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4690.01   (req: >= 5)
Gene RIFs: 263   (req: > 3)
Antibodies: 3031   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
4
4
3
1.1
99.5
mathematical ability
4
3
4
98
heel bone mineral density
3
4
6
97.2
smoking initiation
3
3
3
96.8
smoking behaviour measurement
1
1
1
96.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
3
1.1
99.5
mathematical ability
4
98
heel bone mineral density
6
97.2
smoking initiation
3
96.8
smoking behaviour measurement
1
96.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
neural cell adhesion molecule 1
693789
Mouse
MGI:97281
17967
Rat
RGD:67378
24586
Dog
neural cell adhesion molecule 1
VGNC:43636
479435
Horse
neural cell adhesion molecule 1
VGNC:20573
100062164
Species
Name
OMA
EggNOG
Inparanoid
Macaque
neural cell adhesion molecule 1
Mouse
Rat
Dog
neural cell adhesion molecule 1
Horse
neural cell adhesion molecule 1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (36)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
ECM proteoglycans
Extracellular matrix organization
Protein-Protein Interactions (577)
1 – 10 of 577
SIGLEC9
Tbio
Novelty: 0.01805735
p_int: 0.99949104
p_ni: 0.00050896
Score: 0.623
Data Source: BioPlex,STRINGDB
REEP5
Tbio
Novelty: 0.00160455
p_int: 0.999300831
p_ni: 0.000699165
p_wrong: 4e-9
Data Source: BioPlex
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.994943145
p_ni: 0.005056855
Data Source: BioPlex
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.992477105
p_ni: 0.007522895
Score: 0.168
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.991595231
p_ni: 0.008404769
Data Source: BioPlex
REEP1
Tbio
Novelty: 0.02280713
p_int: 0.986646519
p_ni: 0.013353481
Score: 0.256
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.974016878
p_ni: 0.025983122
Data Source: BioPlex
TMEM185A
Tdark
Novelty: 0.0262898
p_int: 0.945100535
p_ni: 0.054899465
Score: 0.289
Data Source: BioPlex,STRINGDB
TARDBP
Tbio
Novelty: 0.00165455
p_int: 0.902959726
p_ni: 0.097040274
Score: 0.189
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.901427758
p_ni: 0.098572242
Score: 0.166
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  4690.01

PubMed score by year
PubTator Score  3114.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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