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Tbio
NMRK2
Nicotinamide riboside kinase 2

Protein Summary
Description
Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). Reduces laminin matrix deposition and cell adhesion to laminin, but not to fibronectin. Involved in the regulation of PXN at the protein level and of PXN tyrosine phosphorylation. May play a role in the regulation of terminal myogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000168977
  • ENSP00000168977
  • ENSG00000077009
  • ENST00000593949
  • ENSP00000472581
  • ENST00000616156
  • ENSP00000480091

Symbol
  • ITGB1BP3
  • NRK2
  • MIBP
  • NRK2
  • ITGB1BP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.53
biological process
0.51
cell type or tissue
0.5
tissue
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.97   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 103.97   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (35)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Protein-Protein Interactions (47)
1 – 10 of 47
NAPRT
Tbio
Family: Enzyme
Novelty: 0.05728379
Score: 0.963
Data Source: STRINGDB
NMNAT3
Tbio
Family: Enzyme
Novelty: 0.04064292
Score: 0.954
Data Source: STRINGDB
NMNAT2
Tbio
Family: Enzyme
Novelty: 0.02195917
Score: 0.951
Data Source: STRINGDB
PNP
Tclin
Family: Enzyme
Novelty: 0.00222396
Score: 0.947
Data Source: STRINGDB
NMNAT1
Tbio
Family: Enzyme
Novelty: 0.01416255
Score: 0.946
Data Source: STRINGDB
QPRT
Tbio
Family: Enzyme
Novelty: 0.00969466
Score: 0.942
Data Source: STRINGDB
NAMPT
Tchem
Family: Enzyme
Novelty: 0.00099567
Score: 0.94
Data Source: STRINGDB
ITGA7
Tbio
Novelty: 0.01962657
Score: 0.927
Data Source: STRINGDB
NUDT12
Tbio
Family: Enzyme
Novelty: 0.40327445
Score: 0.902
Data Source: STRINGDB
ENPP3
Tbio
Family: Enzyme
Novelty: 0.00239972
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  103.97

PubMed score by year
PubTator Score  26.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer