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Tbio
ANGPTL8
Angiopoietin-like protein 8

Protein Summary
Description
Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels (PubMed:22569073, PubMed:22809513, PubMed:23150577). May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252453
  • ENSP00000252453
  • ENSG00000130173
  • ENST00000616433
  • ENSP00000479969

Symbol
  • C19orf80
  • RIFL
  • RIFL
  • TD26
  • PRO1185
  • PVPA599
  • C19orf80
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.55   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 161   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226.55   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 161   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
2
2
10
95.1
total cholesterol measurement
3
1
1
4
84.8
triglyceride measurement
3
2
3
66.5
low density lipoprotein cholesterol measurement
2
1
1
2.7
53.3
red blood cell distribution width
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
10
95.1
total cholesterol measurement
1
4
84.8
triglyceride measurement
3
66.5
low density lipoprotein cholesterol measurement
1
2.7
53.3
red blood cell distribution width
1
29
Pathways (6)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein remodeling
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein remodeling
Transport of small molecules
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (22)
1 – 10 of 22
ANGPTL3
Tbio
Novelty: 0.00595539
Score: 0.994
Data Source: Reactome,STRINGDB
LPL
Tchem
Family: Enzyme
Novelty: 0.00057058
Score: 0.964
Data Source: STRINGDB
GPIHBP1
Tbio
Novelty: 0.01241227
Score: 0.957
Data Source: STRINGDB
ANGPTL4
Tbio
Novelty: 0.00237867
Score: 0.944
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.851
Data Source: STRINGDB
ANGPTL5
Tbio
Novelty: 0.0856739
Score: 0.731
Data Source: STRINGDB
ANGPTL1
Tbio
Novelty: 0.03123564
Score: 0.726
Data Source: STRINGDB
ANGPTL7
Tbio
Novelty: 0.03893082
Score: 0.725
Data Source: STRINGDB
ANGPTL6
Tbio
Novelty: 0.00538738
Score: 0.707
Data Source: STRINGDB
ANGPTL2
Tbio
Novelty: 0.01134724
Score: 0.677
Data Source: STRINGDB
Publication Statistics
PubMed Score  226.55

PubMed score by year
PubTator Score  48.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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