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Tdark
CFAP57
Cilia- and flagella-associated protein 57

Protein Summary
Description
This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member is thought to function in craniofacial development, possibly in the fusion of lip and palate. A missense mutation in this gene is associated with Van der Woude syndrome 2. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000372492
  • ENSP00000361570
  • ENSG00000243710
  • ENST00000528956
  • ENSP00000435310

Symbol
  • WDR65
  • VWS2
  • WDR65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.79
cell type or tissue
0.64
cellular component
0.64
tissue sample
0.62
protein domain
0.58


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 20   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 20   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2686209
68625
Dog
cilia and flagella associated protein 57
VGNC:39166
475390
Horse
cilia and flagella associated protein 57
VGNC:16456
100053447
Cow
cilia and flagella associated protein 57 [Source:HGNC Symbol;Acc:HGNC:26485]
Pig
cilia and flagella associated protein 57 [Source:HGNC Symbol;Acc:HGNC:26485]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
cilia and flagella associated protein 57
Horse
cilia and flagella associated protein 57
Cow
cilia and flagella associated protein 57 [Source:HGNC Symbol;Acc:HGNC:26485]
Pig
cilia and flagella associated protein 57 [Source:HGNC Symbol;Acc:HGNC:26485]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96MR6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (1)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (47)
1 – 10 of 47
APOD
Tbio
Novelty: 0.0031899
p_int: 0.985123174
p_ni: 0.014876485
p_wrong: 3.41e-7
Data Source: BioPlex
CFAP53
Tbio
Novelty: 0.09266566
Score: 0.729
Data Source: STRINGDB
CCDC74A
Tdark
Novelty: 1.52601156
Score: 0.622
Data Source: STRINGDB
SLC25A21
Tbio
Family: Transporter
Novelty: 0.15355545
Score: 0.591
Data Source: STRINGDB
ZNF676
Tdark
Family: TF
Novelty: 0.23073578
Score: 0.565
Data Source: STRINGDB
PELI2
Tbio
Family: Enzyme
Novelty: 0.16934539
Score: 0.559
Data Source: STRINGDB
TMEM56
Tdark
Novelty: 0.75633366
Score: 0.554
Data Source: STRINGDB
DHX35
Tdark
Family: Enzyme
Novelty: 0.26052594
Score: 0.549
Data Source: STRINGDB
SDSL
Tbio
Family: Enzyme
Novelty: 0.02098867
Score: 0.545
Data Source: STRINGDB
FAM162B
Tdark
Novelty: 1.43078788
Score: 0.511
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.92

PubMed score by year
PubTator Score  1.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer