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Tbio
CLIP1
CAP-Gly domain-containing linker protein 1

Protein Summary
Description
Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking. The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302528
  • ENSP00000303585
  • ENSG00000130779
  • ENST00000358808
  • ENSP00000351665
  • ENST00000537178
  • ENSP00000445531
  • ENST00000540338
  • ENSP00000439093
  • ENST00000620786
  • ENSP00000479322

Symbol
  • CYLN1
  • RSN
  • RSN
  • CLIP
  • CYLN1
  • CLIP170
  • CLIP-170
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
transcription factor perturbation
0.97
drug perturbation
0.96
cellular component
0.92
histone modification site profile
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.23   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 249.23   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
3
2
4
82.2
adiponectin measurement
1
1
1
68.9
hip circumference
1
1
2
35.4
self reported educational attainment
1
1
1
6.1
reticulocyte count
3
1
3
4.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
82.2
adiponectin measurement
1
68.9
hip circumference
2
35.4
self reported educational attainment
1
6.1
reticulocyte count
3
4.1
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (60)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (23)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (209)
1 – 10 of 209
RABEP1
Tbio
Family: Enzyme
Novelty: 0.02318446
p_int: 0.999999997
p_ni: 3e-9
Data Source: BioPlex
GORASP1
Tbio
Novelty: 0.02332405
p_int: 0.999999996
p_ni: 4e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
BMP1
Tchem
Novelty: 0.00299518
p_int: 0.999999574
p_ni: 3.99e-7
p_wrong: 2.7e-8
Score: 0.201
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.999994839
p_ni: 0.000005161
Data Source: BioPlex
CADPS
Tbio
Novelty: 0.01737775
p_int: 0.999984884
p_ni: 0.000015076
p_wrong: 4e-8
Score: 0.695
Data Source: BioPlex,STRINGDB
DAB2IP
Tbio
Novelty: 0.01423445
p_int: 0.99994685
p_ni: 0.000046731
p_wrong: 0.000006419
Score: 0.225
Data Source: BioPlex,STRINGDB
RUNDC3A
Tdark
Novelty: 0.23296904
p_int: 0.999735778
p_ni: 0.000264208
p_wrong: 1.5e-8
Score: 0.214
Data Source: BioPlex,STRINGDB
DCTN1
Tbio
Novelty: 0.00494896
Score: 0.998
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.993
Data Source: Reactome,STRINGDB
PAFAH1B1
Tbio
Family: Enzyme
Novelty: 0.00256206
Score: 0.991
Data Source: STRINGDB
Publication Statistics
PubMed Score  249.23

PubMed score by year
PubTator Score  522.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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