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Tbio
BORA
Protein aurora borealis

Protein Summary
Description
Required for the activation of AURKA at the onset of mitosis. BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377815
  • ENSP00000367046
  • ENSG00000136122

Symbol
  • C13orf34
  • C13orf34
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
virus perturbation
0.88
trait
0.75
kinase
0.68
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
PLK1
Tchem
Family:  Kinase
Novelty:  0.00062799
p_int:  0.999884819
p_ni:  0.000115181
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.999325706
p_ni:  0.000674188
p_wrong:  1.06e-7
Data Source:  BioPlex
TGM2
Tchem
Family:  Enzyme
Novelty:  0.0005293
p_int:  0.990946672
p_ni:  0.009053247
p_wrong:  8e-8
Data Source:  BioPlex
DNA2
Tbio
Family:  Enzyme
Novelty:  0.00195682
p_int:  0.93187279
p_ni:  0.06812721
Score:  0.402
Data Source:  BioPlex,STRINGDB
AARSD1
Tdark
Novelty:  0.75372406
p_int:  0.922733067
p_ni:  0.077266787
p_wrong:  1.46e-7
Data Source:  BioPlex
DNAJB11
Tbio
Novelty:  0.02588745
p_int:  0.919030326
p_ni:  0.080774153
p_wrong:  0.000195521
Score:  0.179
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.918299005
p_ni:  0.081495258
p_wrong:  0.000205737
Data Source:  BioPlex
TSHR
Tclin
Family:  GPCR
Novelty:  0.00074972
p_int:  0.909799974
p_ni:  0.090061699
p_wrong:  0.000138328
Score:  0.189
Data Source:  BioPlex,STRINGDB
UBE3D
Tbio
Family:  Enzyme
Novelty:  0.44919491
p_int:  0.907467358
p_ni:  0.092528359
p_wrong:  0.000004284
Score:  0.192
Data Source:  BioPlex,STRINGDB
WNT4
Tbio
Novelty:  0.00276803
p_int:  0.884063548
p_ni:  0.115936451
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Transition
Reactome
Mitotic G2-G2/M phases
Reactome
Regulation of PLK1 Activity at G2/M Transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
G2/M Transition
Mitotic G2-G2/M phases
Regulation of PLK1 Activity at G2/M Transition
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
71.2
mean corpuscular hemoglobin concentration
1
1
1
32.9
testosterone measurement
1
1
1
6.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
71.2
mean corpuscular hemoglobin concentration
1
32.9
testosterone measurement
1
6.6
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
bora, aurora kinase A activator
VGNC:9842
467283
Macaque
bora, aurora kinase A activator
693798
Mouse
MGI:1924994
77744
Rat
RGD:1309522
306102
Dog
bora, aurora kinase A activator
VGNC:38499
476944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
bora, aurora kinase A activator
Macaque
bora, aurora kinase A activator
Mouse
Rat
Dog
bora, aurora kinase A activator
Publication Statistics
PubMed Score 27.01
PubMed score by year
PubTator Score 16.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title