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Tbio
YAP1
Transcriptional coactivator YAP1

Protein Summary
Description
Transcriptional regulator which can act both as a coactivator and a corepressor and is the critical downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:17974916, PubMed:18280240, PubMed:18579750, PubMed:21364637). The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:18158288). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts via ARHGAP18, a Rho GTPase activating protein that suppresses F-actin polymerization (PubMed:25778702). Plays a key role to control cell proliferation in response to cell contact. Phosphorylation of YAP1 by LATS1/2 inhibit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282441
  • ENSP00000282441
  • ENSG00000137693
  • ENST00000345877
  • ENSP00000331023
  • ENST00000524575
  • ENSP00000435602
  • ENST00000526343
  • ENSP00000434134
  • ENST00000531439
  • ENSP00000431574
  • ENST00000537274
  • ENSP00000445635
  • ENST00000615667
  • ENSP00000478927
  • ENST00000629586
  • ENSP00000487519

Symbol
  • YAP65
  • YAP
  • YKI
  • COB1
  • YAP2
  • YAP65
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.98
biological term
0.96
ligand (protein) perturbation
0.96
kinase
0.9
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 989.1   (req: < 5)
Gene RIFs: 584   (req: <= 3)
Antibodies: 815   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 989.1   (req: >= 5)
Gene RIFs: 584   (req: > 3)
Antibodies: 815   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 46
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
3
5
98.4
3
2
1
1.2
96.7
pulse pressure measurement
1
1
1
58.6
parental genotype effect measurement
1
1
1
49.2
birth weight
1
1
1
49.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
5
98.4
1
1.2
96.7
pulse pressure measurement
1
58.6
parental genotype effect measurement
1
49.2
birth weight
1
49.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Yes associated protein 1
VGNC:3038
451506
Macaque
Yes associated protein 1
704382
Mouse
MGI:103262
22601
Rat
RGD:1306035
363014
Dog
Yes associated protein 1
VGNC:49698
479465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Yes associated protein 1
Macaque
Yes associated protein 1
Mouse
Rat
Dog
Yes associated protein 1
Protein Structure (25 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P46937-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 25
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (54)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear signaling by ERBB4
Reactome
RNA Polymerase II Transcription
Reactome
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear signaling by ERBB4
RNA Polymerase II Transcription
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Gene Ontology Terms (53)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (294)
1 – 10 of 294
TEAD4
Tbio
Family: TF
Novelty: 0.0114979
p_int: 0.999999906
p_ni: 9.4e-8
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TEAD2
Tbio
Family: TF
Novelty: 0.02487024
p_int: 0.999999866
p_ni: 1.34e-7
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999999817
p_ni: 1.83e-7
Score: 0.583
Data Source: BioPlex,STRINGDB
PTPN14
Tbio
Family: Enzyme
Novelty: 0.01333024
p_int: 0.999995007
p_ni: 0.000004993
p_wrong: 1e-9
Score: 0.848
Data Source: BioPlex,STRINGDB
PRRG4
Tdark
Novelty: 0.19371546
p_int: 0.999881558
p_ni: 0.000118441
p_wrong: 1e-9
Score: 0.559
Data Source: BioPlex,STRINGDB
LAIR2
Tbio
Novelty: 0.06117644
p_int: 0.996231178
p_ni: 0.003768822
Data Source: BioPlex
CYYR1
Tbio
Novelty: 0.19732526
p_int: 0.986885651
p_ni: 0.013114281
p_wrong: 6.8e-8
Score: 0.313
Data Source: BioPlex,STRINGDB
DEFA6
Tbio
Novelty: 0.0363171
p_int: 0.979358508
p_ni: 0.020641488
p_wrong: 4e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
ARRDC1
Tbio
Novelty: 0.10481621
p_int: 0.972691746
p_ni: 0.026646763
p_wrong: 0.000661491
Score: 0.463
Data Source: BioPlex,STRINGDB
MPP5
Tbio
Novelty: 0.01707773
p_int: 0.897490276
p_ni: 0.102500621
p_wrong: 0.000009103
Score: 0.523
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  989.10

PubMed score by year
PubTator Score  1151.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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