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Tbio
PPM1K
Protein phosphatase 1K, mitochondrial

Protein Summary
Description
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000608933
  • ENSP00000477341
  • ENSG00000163644

Symbol
  • PP2CM
  • BDP
  • PTMP
  • PP2Cm
  • MSUDMV
  • PP2Ckappa
  • UG0882E07
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.8
transcription factor binding site profile
0.75
microRNA
0.69
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.31   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.31   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
1
2
60.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
2
60.2
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
DBT
Tbio
Family: Enzyme
Novelty: 0.0070589
p_int: 0.999999682
p_ni: 1.14e-7
p_wrong: 2.05e-7
Score: 0.97
Data Source: BioPlex,Reactome,STRINGDB
BCKDHB
Tbio
Family: Enzyme
Novelty: 0.02234969
p_int: 0.999997965
p_ni: 0.000001651
p_wrong: 3.84e-7
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
BCKDHA
Tbio
Family: Enzyme
Novelty: 0.01684893
p_int: 0.993705969
p_ni: 0.00629403
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00214298
Score: 0.907
Data Source: Reactome,STRINGDB
PSPH
Tbio
Family: Enzyme
Novelty: 0.01078634
Score: 0.904
Data Source: STRINGDB
PPTC7
Tdark
Family: Enzyme
Novelty: 0.36770849
Score: 0.717
Data Source: STRINGDB
FAM110B
Tbio
Novelty: 0.35516609
Score: 0.714
Data Source: STRINGDB
HDHD5
Tdark
Novelty: 0.95671879
Score: 0.685
Data Source: STRINGDB
BCKDK
Tbio
Family: Kinase
Novelty: 0.03296998
Score: 0.639
Data Source: STRINGDB
MGAM
Tclin
Family: Enzyme
Novelty: 0.00045865
Score: 0.554
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.31

PubMed score by year
PubTator Score  10.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer