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Tbio
FBXW2
F-box/WD repeat-containing protein 2

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000608872
  • ENSP00000476369
  • ENSG00000119402

Symbol
  • FBW2
  • FWD2
  • Md6
  • FBW2
  • Fwd2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.99
kinase perturbation
0.95
histone modification site profile
0.89
transcription factor binding site profile
0.88


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.95   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.95   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box and WD repeat domain containing 2
700958
Mouse
MGI:1353435
30050
Rat
RGD:1310460
311881
Dog
F-box and WD repeat domain containing 2
VGNC:40794
610990
Horse
F-box and WD repeat domain containing 2
VGNC:17965
100067698
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box and WD repeat domain containing 2
Mouse
Rat
Dog
F-box and WD repeat domain containing 2
Horse
F-box and WD repeat domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UKT8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (358)
1 – 10 of 358
SKP1
Tbio
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999999985
p_ni: 1.3e-8
p_wrong: 2e-9
Score: 0.982
Data Source: BioPlex,STRINGDB
ARIH1
Tbio
Family: Enzyme
Novelty: 0.0258739
p_int: 0.999999929
p_ni: 6.7e-8
p_wrong: 4e-9
Score: 0.516
Data Source: BioPlex,STRINGDB
FBXW7
Tbio
Novelty: 0.00180856
p_int: 0.999999859
p_ni: 1.41e-7
Score: 0.931
Data Source: BioPlex,STRINGDB
FBXO17
Tbio
Novelty: 0.1320754
p_int: 0.999965816
p_ni: 0.000034181
p_wrong: 3e-9
Score: 0.946
Data Source: BioPlex,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.999963419
p_ni: 0.000036571
p_wrong: 1.1e-8
Score: 0.954
Data Source: BioPlex,STRINGDB
TTC9C
Tdark
Novelty: 0.85949913
p_int: 0.999949095
p_ni: 0.000049814
p_wrong: 0.000001091
Data Source: BioPlex
SPANXN3
Tdark
Novelty: 4.06770018
p_int: 0.999920494
p_ni: 0.000010641
p_wrong: 0.000068865
Score: 0.859
Data Source: BioPlex,STRINGDB
FBXO7
Tbio
Novelty: 0.01151907
p_int: 0.996836236
p_ni: 0.000534718
p_wrong: 0.002629046
Score: 0.932
Data Source: BioPlex,STRINGDB
CUL1
Tbio
Novelty: 0.00244476
Score: 0.979
Data Source: STRINGDB
CUL2
Tbio
Novelty: 0.00512916
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  58.95

PubMed score by year
PubTator Score  5.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer